DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and kcnv2b

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_001122212.1	Gene:	kcnv2b / 567780	ZFINID:	ZDB-GENE-060526-28	Length:	527	Species:	Danio rerio

Alignment Length:	438	Identity:	130/438 - (29%)
Similarity:	215/438 - (49%)	Gaps:	61/438 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LLINVSGRRFETWRNTLEKYPDTLLG----SNEREFFYD-------EDCKEYFFDRDPDIFRHIL 96
            |.:||.|:.:........:||.|.||    |.:.....|       :| .|||||||||:|..|.
Zfish    82 LNLNVGGKSYRITYKMAARYPQTRLGRLAMSTDLNMKMDLCDDYVVKD-NEYFFDRDPDVFNSIF 145

  Fly    97 NYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDKLSENG---D 158
            |:||||.|......|..::.||::::|:.......||.....::..|..|:|...|..|..   :
Zfish   146 NFYRTGVLWIKDELCPRNFLEEISYWGVRIKYSQRCCRILLEEKNDELCEQLKVQKELERELEIE 210

  Fly   159 QNLQQLTNM-----RQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVPCGHRPGRAGT 218
            :|.:...:|     |:.:|...|.|.:|..|.:....:..|:.:|::...:.||.........|.
Zfish   211 ENEEAFDDMILGESRRSLWDFMEKPFSSIPAKLMAVTSSMFVLISLVTMTLSTVEEMENIESEGK 275

  Fly   219 LPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIMPYYIGLGITDND 283
             ..||       .::..|:..||.|||||:.:.||.|:|.:|:::.:|::||:|..:.. :.:|.
Zfish   276 -NYGE-------FVENLCITFFTIEYLLRVISTPDICRFFKSMLNAVDLMAILPQILQF-MLENF 331

  Fly   284 DVSGA-------------------FVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLVF 329
            :..|:                   ...:|:.|:||:.|.:|||.|||..|:|||.|..::|.|..
Zfish   332 ETFGSRNQSADMETVGQVGKVGQVLRIMRLLRIFRVLKLARHSTGLRAFGFTLKQCYQQVGCLFL 396

  Fly   330 SLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSG 394
            .:||.|..|:.:::..|.:|..|||||||.::|:..|:::|:|||||.|||:.|:|....|...|
Zfish   397 FIAMGIFTFSAMVYSVEYDVPKTNFTSIPHSWWWASVSISTVGYGDMYPETLLGRIFAFGCISFG 461

  Fly   395 VLVIALPVPVIVSNFSRIY----------HQNQRADKR---KAQRKAR 429
            :::..||:.::.:.||..|          |...|.:..   :|::|.|
Zfish   462 IILNGLPISILFNKFSDYYAKLKSHECPSHMKNRGNVNFIPRAKKKLR 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	35/111 (32%)
		Ion_trans	188..415	CDD:395416	77/255 (30%)
		DUF3399	445..540	CDD:403174
kcnv2b	NP_001122212.1	BTB	82..173	CDD:295341	32/91 (35%)
		BTB	84..187	CDD:197585	34/103 (33%)
		Ion_trans	279..484	CDD:278921	71/212 (33%)
		Ion_trans_2	409..478	CDD:285168	27/68 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810