DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and kcng4b

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	XP_009301775.1	Gene:	kcng4b / 566228	ZFINID:	ZDB-GENE-130530-634	Length:	535	Species:	Danio rerio

Alignment Length:	480	Identity:	160/480 - (33%)
Similarity:	255/480 - (53%)	Gaps:	65/480 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 RKTDDEKL-LINVSGRRFETWRNTLEKYPDTLLG-----SNEREFF-----YDEDCKEYFFDRDP 89
            :..|..|| ||||.|.|:....:||:::|.:.||     |:..:..     |||..:|:||||..
Zfish    54 KDVDHSKLALINVGGDRYTFPWSTLDEFPLSRLGQLRHCSSPDDIAQLCDDYDEARREFFFDRSS 118

  Fly    90 DIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCC-------YEDYRDRKRENAER 147
            ..||.|||:...|||...:..|..|..:||.::||.|..:..||       .||..::|::..||
Zfish   119 VAFRVILNFLAAGKLRLLRQVCAVSLSDELTYWGIDPVHMERCCRRKLLSRVEDVAEKKKKEDER 183

  Fly   148 -----LMDDKLSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETV 207
                 .:...|::  |:...:|.|..|::   .||||:..:..:|...:...|||:|::..:.|:
Zfish   184 KQKRHALQRPLAQ--DKGFIRLMNRLQEI---VENPHSGWAGKLFACFSVVMIAVTVISLCISTL 243

  Fly   208 PCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIMP 272
            |.....|.     |.|:.:.:|. ::|.||..|:.|:|||...|..:.:|:|:.:::|||:||:|
Zfish   244 PDHENRGE-----CTEKCRNIFI-VETVCVAWFSMEFLLRFLQAESKMQFLRNPLNVIDVIAILP 302

  Fly   273 YYIGLGITDNDDVS------GAFVT----------LRVFRVFRI---FKFSRHSQGLRILGYTLK 318
            |||.| :.|::|.|      ||..:          |||.|..||   .:.:|||.||:.||.|::
Zfish   303 YYISL-VVDSEDTSDEAELNGAGTSRGYLDKLGLILRVMRALRILYVMRLARHSLGLQTLGLTMQ 366

  Fly   319 SCASELGFLVFSLAMAIIIFATVMFYAEK-----NVNGTN-FTSIPAAFWYTIVTMTTLGYGDMV 377
            ....|.|.|:..|.:|:.:|:.::..|||     ...|.| |:||||::|:.|::|||:||||||
Zfish   367 RSMREFGLLLLFLCVAVALFSPLVHLAEKEFSKGKATGPNSFSSIPASYWWAIISMTTVGYGDMV 431

  Fly   378 PETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSGA 442
            |.:|.|::|.....|||:|::|.|...|...|||.||:.:| ::....::.|:| |..|.|...|
Zfish   432 PYSIPGQVVAFSSILSGILIMAFPATSIFHVFSRSYHELKR-EQEMIYKEERVA-ILDATAKEDA 494

  Fly   443 AFVSKKKAAEARWA-AQESGIELDD 466
            ..:.|:.:..  || |..:.:..|:
Zfish   495 QRLLKRDSFS--WAIANRNSLRKDN 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	43/125 (34%)
		Ion_trans	188..415	CDD:395416	92/251 (37%)
		DUF3399	445..540	CDD:403174	5/23 (22%)
kcng4b	XP_009301775.1	BTB_2	64..161	CDD:280393	34/96 (35%)
		BTB	<102..163	CDD:197585	24/60 (40%)
		Ion_trans	259..471	CDD:278921	84/213 (39%)
		Ion_trans_2	<414..465	CDD:285168	23/50 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810