DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and kcnc1a

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	XP_005168950.1	Gene:	kcnc1a / 565419	ZFINID:	ZDB-GENE-061220-10	Length:	609	Species:	Danio rerio

Alignment Length:	542	Identity:	190/542 - (35%)
Similarity:	284/542 - (52%)	Gaps:	78/542 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 DEK--LLINVSGRRFETWRNTLEKYPDTLLG-----SNEREFFYDEDCKEYFFDRDPDIFRHILN 97
            |||  ::|||.|.|.:|:|:||...|.|.|.     .....|.||....|:||||.|.:|.||||
Zfish     5 DEKDRVVINVGGIRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDAQIDEFFFDRHPGVFAHILN 69

  Fly    98 YYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRD-RKRENA---------ERLMDDK 152
            ||||||||.|...|...|:|||||:||....:..||:..||. |:.|.|         |...||.
Zfish    70 YYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHREAEEALDSFGGGPVEMGNDDM 134

  Fly   153 LSE------NGDQNLQQLTNM-----------------RQKMWRAFENPHTSTSALVFYYVTGFF 194
            .:|      :||:.|:....:                 ::::|..||:|::|..|....:.:.||
Zfish   135 DTEALGDPGDGDEELEMTKRLAVGDSPDTKGAGFWQRWQRRVWALFEDPYSSKYARWVAFASLFF 199

  Fly   195 IAVSVMANVVET----VPCGHRPGRAGTLPCGERY-----KIVFFC-LDTACVMIFTAEYLLRLF 249
            |.||:....:||    .|..:|. ...|.....|:     .:|:.. ::..||:.||.|:|:|:.
Zfish   200 ILVSITTFCLETHEAFNPIINRT-YVNTQDNTSRFHLETETVVYLTYIEGVCVVWFTFEFLMRVT 263

  Fly   250 AAPDRCKFVRSVMSIIDVVAIMPYYI-----GLGITDNDDVSGAFVTLRVFRVFRIFKFSRHSQG 309
            ..||:.||:::.::|||.|||:|:|:     ||..::..||.|....:|..|:.||||.:||..|
Zfish   264 FCPDKKKFIKNTLNIIDFVAILPFYLEVGLSGLSSSEAKDVLGFLRVVRFVRILRIFKLTRHFVG 328

  Fly   310 LRILGYTLKSCASELGFLVFSLAMAIIIFATVMFYAEK---NVNG------TNFTSIPAAFWYTI 365
            ||:||:||::..:|...|:..||:.::||||:::|||:   |.|.      |:|.:||..||:.:
Zfish   329 LRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGANPNDPRASEHTHFKNIPIGFWWAV 393

  Fly   366 VTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYH---QNQRADKRKAQ-- 425
            |||||||||||.|:|.:|.:||.:|:|:|||.||:||||||:||...|.   ..|:..|:|.:
Zfish   394 VTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHI 458

  Fly   426 -RKARLARIRIAKASSGAAFVSKKKAAEARWAAQESGIELDDNYRDEDIFELQHHHLLRCLEKTT 489
             |..:|......|::..:...|.:.:.....||||..:|:  |..|..:    :....:......
Zfish   459 PRAPQLGSANYCKSAMNSPHHSPQISEHCALAAQEEILEM--NRADPKV----NGEAAKAALANE 517

  Fly   490 DREFVELEI-PFNGQPKRPGSP 510
            |...::..| |.:||...|..|
Zfish   518 DCPHIDQAISPEDGQIFNPNEP 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	52/111 (47%)
		Ion_trans	188..415	CDD:395416	102/253 (40%)
		DUF3399	445..540	CDD:403174	15/67 (22%)
kcnc1a	XP_005168950.1	BTB	10..112	CDD:197585	48/101 (48%)
		BTB_2	10..104	CDD:280393	44/93 (47%)
		Ion_trans	243..445	CDD:278921	90/201 (45%)
		Ion_trans_2	<388..435	CDD:285168	30/46 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810