DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shal and kcns3a

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_001122196.1	Gene:	kcns3a / 565375	ZFINID:	ZDB-GENE-080723-45	Length:	499	Species:	Danio rerio

Alignment Length:	473	Identity:	136/473 - (28%)
Similarity:	244/473 - (51%)	Gaps:	70/473 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RRKTDDEKLLINVSGRRFETWRNTLEKYPDTLLG-----SNEREFF-----YDEDCKEYFFDRDP 89
            ||..::..:.:||.|.:.:..|..|:::|.|.|.     |:|....     |....:||:|||:|
Zfish     9 RRGPEESFINLNVGGFKQQVERVVLQRFPHTRLARLLYCSSEAAILQLCDDYAAADREYYFDRNP 73

  Fly    90 DIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENA-------ER 147
            ..||::||:|.|||:|..:..|:.|:.:||.::||....:..||...::::| ||.       |.
Zfish    74 CFFRYVLNFYHTGKIHLMEELCVFSFSQELEYWGIKELHLDTCCSNRFQEQK-ENMGDPDWGNED 137

  Fly   148 LMDDKLSENGDQNLQQLT---------------NMRQKMWRAFENPHTSTSALVFYYVTGFFIAV 197
            ...::|.::.|.::::|:               ..|:::|...|||..|.||.:....:...:.:
Zfish   138 DPQNQLQDSLDSSMEELSAFDKDLEKFEGTWCAEKRKELWLRLENPGYSRSAKILAVFSLSVVLI 202

  Fly   198 SVMANVVETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVM 262
            |::|..:.::|..|:......    |....|....:|.||:.|:.|:::||...|...||:.:.:
Zfish   203 SIIAMCIHSMPEFHQKDANEK----EVENPVLDVFETFCVLWFSLEFIVRLVVTPCLRKFICNAL 263

  Fly   263 SIIDVVAIMPYYIGLGITDND--------DVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKS 319
            ::||..:|:|:|..|.....|        :|......||:.|:|||.|.:|||.|||.||.||:.
Zfish   264 NMIDFASIVPFYATLAFEKVDPEESEELENVGRVVQILRLMRIFRILKLARHSVGLRSLGATLRH 328

  Fly   320 CASELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGK 384
            ...|:|.|:..|::.|.||:.::::.|:..:.:...:||..:|:..::|||:||||..|.|:.||
Zfish   329 SYHEVGLLILFLSVGISIFSVLIYFVEREDHESELQTIPVGWWWATISMTTVGYGDTYPVTLPGK 393

  Fly   385 IVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRA----------DKRK--------------AQ 425
            ::|.:|.:.|:||:|||:.:|.:.||: |:|.|:|          |:::              :|
Zfish   394 LIGTLCIICGLLVVALPISIIFNKFSK-YYQRQKALVESDQLQTEDEKQPDLSMPFLHIADLYSQ 457

  Fly   426 RKARLARIRIAKASSGAA 443
            :...||....:::|.|.|
Zfish   458 KMNSLAHSASSRSSEGDA 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	37/118 (31%)
		Ion_trans	188..415	CDD:395416	75/234 (32%)
		DUF3399	445..540	CDD:403174
kcns3a	NP_001122196.1	BTB_2	17..116	CDD:308049	32/98 (33%)
kcns3a	NP_001122196.1	Ion_trans	189..426	CDD:306908	77/241 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810