DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and kcng2

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	XP_690900.2	Gene:	kcng2 / 562421	ZFINID:	ZDB-GENE-100701-1	Length:	546	Species:	Danio rerio

Alignment Length:	477	Identity:	158/477 - (33%)
Similarity:	231/477 - (48%)	Gaps:	82/477 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 DEKLLINVSGRRFETWRNTLEKYPDTLLG-----SNEREFF-----YDEDCKEYFFDRDPDIFRH 94
            |...:|||.|.|:....:|||::|.|.||     :|..|..     ||..|.|:||||.|..||.
Zfish    69 DRTAIINVGGIRYRIPWSTLEEFPLTRLGRLHNCNNAEEILDLCDDYDARCNEFFFDRSPSAFRS 133

  Fly    95 ILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDKLSEN--- 156
            |:.:...|||...:..|..|:.|||:::|:....:..||....|.|:.|..|||   :|.|.
Zfish   134 IVTFLAAGKLRLLREMCALSFQEELSYWGVEEASLEWCCLRKLRLRQEEQRERL---RLEEEEAE 195

  Fly   157 -------------GDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVP 208
                         |.....:|:.....:....||||:.....:|..::..|:|::.:...|.|:|
Zfish   196 LTSPHSCEEAPAVGSPEEGRLSGCMHSLRDMVENPHSGIPGKIFACLSVVFVAITAVTLCVSTMP 260

  Fly   209 CGHRPGRAGTLPCGER-YKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIMP 272
            ........|  .|.:| |.|  |.|:|.||..|:.|:|||......:|.|:|:.::|||||||:|
Zfish   261 DLREEEERG--ECSQRCYNI--FVLETVCVGWFSLEFLLRFIQTQSKCTFLRTPLNIIDVVAILP 321

  Fly   273 YYIGLGITD------------NDDVSGAFVTLRVFRVFRIF---KFSRHSQGLRILGYTLKSCAS 322
            |||.| |.|            |:.:....:.|||.|..|||   :.:|||.||:.||.|::.|..
Zfish   322 YYITL-IVDSMSVGDRPAGSGNNYLEKVGLVLRVLRALRIFYVMRLARHSLGLQTLGLTVRRCTR 385

  Fly   323 ELGFLVFSLAMAIIIFATVMFYAEKNVNG-TNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIV 386
            |.|.|:..|.:|:.:|:.::|.||..:.. ..|||||.::|:.:::|||:|||||||.:|.|::|
Zfish   386 EFGLLLLFLCVAMALFSPLVFLAESELGAKQEFTSIPGSYWWAVISMTTVGYGDMVPRSIPGQVV 450

  Fly   387 GGVCSLSGVLVIALPVPVIVSNFSRIY------------HQNQRADKRKAQRK------------ 427
            .....|||:|::|.||..|...|||.|            |:....|..|:|..
Zfish   451 ALSSILSGILLMAFPVTSIFHTFSRSYLELKEEQNRATRHKPDSQDSTKSQNSEDSQDTDSSIHG 515

  Fly   428 -------ARLARIRIAKASSGA 442
                   :.|.|..:|.||.||
Zfish   516 ITETTAVSALHRRSVAVASQGA 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	40/113 (35%)
		Ion_trans	188..415	CDD:395416	94/255 (37%)
		DUF3399	445..540	CDD:403174
kcng2	XP_690900.2	BTB	72..172	CDD:197585	35/99 (35%)
		BTB_2	73..171	CDD:280393	35/97 (36%)
		Ion_trans	273..481	CDD:278921	87/210 (41%)
		Ion_trans_2	<416..475	CDD:285168	28/58 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810