DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and kcns3b

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_001032460.1	Gene:	kcns3b / 558674	ZFINID:	ZDB-GENE-051120-78	Length:	424	Species:	Danio rerio

Alignment Length:	419	Identity:	127/419 - (30%)
Similarity:	222/419 - (52%)	Gaps:	53/419 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DDEKLLINVSGRRFETWRNTLEKYPDTLLGS-----NEREFF-----YDEDCKEYFFDRDPDIFR 93
            :::.:.:|:.|...:..|..|.::|.|.:..     ::....     |....:||:|||.|.:|.
Zfish    13 EEDLVNLNIGGIHHKVERCVLLRFPHTRVAQLIQCHSDAAILELCDDYSPTEQEYYFDRSPQVFH 77

  Fly    94 HILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDKLSENGD 158
            .:||:||||..|..:..|:..:.:|:.::|:....:..||.|.:.:||.|: |.....:.|:|..
Zfish    78 CVLNFYRTGHFHTLEELCVFCFSQEIEYWGLCELDLDACCLEWFLERKDEH-ELNSSGQSSKNAS 141

  Fly   159 QNLQQLT-------------NMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVPCG 210
            .....:|             ::|:.||...|:|..|..:.....|:...|.:|::|..|.::|
Zfish   142 SGEISVTSEDLWKSEGMRCSDVRKLMWETLEDPQHSRCSRGVAAVSVLVILISILAMCVHSLP-- 204

  Fly   211 HRPGRAGTLPCGERYKI-----VFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAI 270
                       ..||:.     |...::..|::.|:.|:.||:.|||...:|:.:.:::|||.:|
Zfish   205 -----------EFRYQTDGEHSVLDSVELFCIVFFSVEFFLRVIAAPQPLRFLGNPLNMIDVASI 258

  Fly   271 MPYYIGLGI--TDNDDVS--------GAFV-TLRVFRVFRIFKFSRHSQGLRILGYTLKSCASEL 324
            :|:||.|.:  .|.:|..        |..| .||:.|.||:.|.:|||:|:|..|.||.:|..|:
Zfish   259 LPFYITLAVERLDEEDKEENQSLVNMGRVVQVLRLMRSFRVLKLARHSEGMRAFGETLMNCQCEV 323

  Fly   325 GFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGV 389
            |.||..:.:.|..|:|.::|.||....:..:|||..:|:.|::|||:||||:.|.|:||:||..|
Zfish   324 GLLVLFITVGISFFSTFIYYTEKEEASSQLSSIPICWWWGIISMTTVGYGDVYPLTVAGRIVATV 388

  Fly   390 CSLSGVLVIALPVPVIVSNFSRIYHQNQR 418
            |.|.|:|||:||:.:|::|||:.:.:|::
Zfish   389 CILCGLLVISLPITIIMNNFSKYFEKNRK 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	29/114 (25%)
		Ion_trans	188..415	CDD:395416	86/242 (36%)
		DUF3399	445..540	CDD:403174
kcns3b	NP_001032460.1	BTB	17..117	CDD:197585	24/99 (24%)
		BTB_2	17..116	CDD:280393	24/98 (24%)
		Ion_trans	205..414	CDD:278921	80/208 (38%)
		Ion_trans_2	329..410	CDD:285168	36/80 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810