DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and kcnq1.1

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_001116714.1	Gene:	kcnq1.1 / 557498	ZFINID:	ZDB-GENE-061214-5	Length:	655	Species:	Danio rerio

Alignment Length:	274	Identity:	74/274 - (27%)
Similarity:	121/274 - (44%)	Gaps:	60/274 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 WRAFENPHTSTSALVFYYVTGFFIAVS-VMANVVETVPCGHRPGRAGTLPCGERYKIV----FFC 231
            |:.|           .|:.|.|.|.:| ::.:|:.|:               :.|:.:    .|.
Zfish    88 WKCF-----------VYHFTVFLIVLSCLILSVLSTI---------------DEYQALANKTLFW 126

  Fly   232 LDTACVMIFTAEYLLRLFAAPDRCKFV---------RSVMSIIDVVAIMPYYIGLGITDNDDV-- 285
            ::...||.|..||::||::|..|.|:|         |..:|:||::.::...|.|....|..|
Zfish   127 MELVLVMFFGVEYVVRLWSAGCRSKYVGILGRLRFARKPISVIDLIVVVASIIVLAFGSNGQVFA 191

  Fly   286 SGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASEL------GFLVFSLAMAIIIFATVMFY 344
            :.|...:|..::.|:....|.....|:||..:.....||      |||.       :||::...|
Zfish   192 TSAVRGVRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLG-------LIFSSYFVY 249

  Fly   345 -AEKNV----NGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPV 404
             |||:.    ..:.|.|...|.|:.:||:||:||||.||:|..||.:....|:..:...|||..:
Zfish   250 LAEKDAVDDHGNSGFGSYADALWWGVVTVTTIGYGDKVPQTWIGKTIASCFSVFAISFFALPAGI 314

  Fly   405 IVSNFSRIYHQNQR 418
            :.|.|:....|.||
Zfish   315 LGSGFALKVQQKQR 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727
		Ion_trans	188..415	CDD:395416	69/253 (27%)
		DUF3399	445..540	CDD:403174
kcnq1.1	NP_001116714.1	Ion_trans	121..327	CDD:278921	62/212 (29%)
		Ion_trans_2	238..317	CDD:285168	29/85 (34%)
		KCNQ_channel	<503..>561	CDD:281513
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810