DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and Kcnf1

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_963289.2	Gene:	Kcnf1 / 382571	MGIID:	2687399	Length:	505	Species:	Mus musculus

Alignment Length:	439	Identity:	145/439 - (33%)
Similarity:	232/439 - (52%)	Gaps:	39/439 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PPPMPKDRRKTDDEKLLINVSGRRFETWRNTLEKYPDT--------LLGSNEREFF----YDEDC 80
            |.|..:|....:|.::::||.|.|...:.:.|.:||:|        |.|..:..|.    ||...
Mouse    22 PEPGSQDSVAGEDIEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDDYDPGK 86

  Fly    81 KEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENA 145
            :|::||||||.|:.::..|..|::|..|..|...:..|:.|:.:....:.||| :.:...|||..
Mouse    87 REFYFDRDPDAFKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCC-KSHLSEKREEL 150

  Fly   146 E------RLMDDKLSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVV 204
            |      :|:.|.|..:..:.  :....::.:|:..|.|.:|..|.|...::...|.||.:...:
Mouse   151 EEIARRVQLILDDLGVDAAEG--RWRRCQKCVWKFLEKPESSCPARVVAVLSFLLILVSSVVMCM 213

  Fly   205 ETVP---CGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIID 266
            .|:|   .....|.....|..|.       ::|||:..||.|||||||::|::..|..|.|:|:|
Mouse   214 GTIPELQVVDSEGNRVEHPTLEN-------VETACIGWFTLEYLLRLFSSPNKLHFALSFMNIVD 271

  Fly   267 VVAIMPYYIGLGIT-------DNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASEL 324
            |:||:|:|:.|.:|       :..:|..|...||:.|:.||||.:|||.||:.|.|.||....||
Mouse   272 VLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSFKEL 336

  Fly   325 GFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGV 389
            |.|:..||:.|.:|:.:.:..|::...|.|.|||.:||:.|:||||:||||:.|:|..||:...:
Mouse   337 GLLLMYLAVGIFVFSALGYTMEQSHPETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLNAAI 401

  Fly   390 CSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKA 438
            ..|.||:.||||:..|::||.| |:..||..:..|:.:..|..:..:.|
Mouse   402 SFLCGVIAIALPIHPIINNFVR-YYNKQRVLETAAKHELELMELNSSSA 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	37/127 (29%)
		Ion_trans	188..415	CDD:395416	92/236 (39%)
		DUF3399	445..540	CDD:403174
Kcnf1	NP_963289.2	BTB_POZ_Kv5_KCNF1	35..150	CDD:349690	34/115 (30%)
Kcnf1	NP_963289.2	Ion_trans	193..429	CDD:366146	94/243 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810