DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and KCNS3

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_001269357.1	Gene:	KCNS3 / 3790	HGNCID:	6302	Length:	491	Species:	Homo sapiens

Alignment Length:	489	Identity:	160/489 - (32%)
Similarity:	251/489 - (51%)	Gaps:	76/489 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DDEKLLINVSGRRFETWRNTLEKYPDTLLGS-----NEREFF-----YDEDCKEYFFDRDPDIFR 93
            |:|.:.:||.|.:....::||.::|.|.||.     :|....     |....|||:|||:|.:||
Human    13 DEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFR 77

  Fly    94 HILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDKLSE-NG 157
            ::||:|.|||||..:..|:.|:.:|:.::||....|..||...|::||.||.|:..|.|..: :.
Human    78 YVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNRYQERKEENHEKDWDQKSHDVST 142

  Fly   158 DQNLQQLT---------------NMRQKMWRAFENPHTSTSALVFYYVTGFFIAVS----VMANV 203
            |.:.::.:               .:|:|:|...|||        .|.::...||:|    |:|::
Human   143 DSSFEESSLFEKELEKFDTLRFGQLRKKIWIRMENP--------AYCLSAKLIAISSLSVVLASI 199

  Fly   204 VETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVV 268
            |  ..|.|....... ..||....|...::.||:..||.|..:||.|||.:.||.::.::|||.|
Human   200 V--AMCVHSMSEFQN-EDGEVDDPVLEGVEIACIAWFTGELAVRLAAAPCQKKFWKNPLNIIDFV 261

  Fly   269 AIMPYYIGLGITDNDDVS------GAFV-TLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGF 326
            :|:|:|..|.:...::.|      |..| .||:.|:|||.|.:|||.|||.||.||:....|:|.
Human   262 SIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGL 326

  Fly   327 LVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCS 391
            |:..|::.|.||:.:::..||:.:.::.||||..:|:..::|||:||||..|.|:|||::...|.
Human   327 LLLFLSVGISIFSVLIYSVEKDDHTSSLTSIPICWWWATISMTTVGYGDTHPVTLAGKLIASTCI 391

  Fly   392 LSGVLVIALPVPVIVSNFSRIYHQNQRAD----KRKAQRK-------------ARLARIRIAKAS 439
            :.|:||:|||:.:|.:.||:.|.:.:..|    ...|..|             |:.....|...|
Human   392 ICGILVVALPITIIFNKFSKYYQKQKDIDVDQCSEDAPEKCHELPYFNIRDIYAQRMHTFITSLS 456

  Fly   440 SGAAFVSKKKAAEARWAAQESGIELDDNYRDEDI 473
            |....||...:.:|      |.||  ||   |||
Human   457 SVGIVVSDPDSTDA------SSIE--DN---EDI 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	41/114 (36%)
		Ion_trans	188..415	CDD:395416	89/237 (38%)
		DUF3399	445..540	CDD:403174	11/29 (38%)
KCNS3	NP_001269357.1	BTB_2	17..116	CDD:280393	34/98 (35%)
		BTB	44..122	CDD:197585	27/77 (35%)
		Ion_trans	219..417	CDD:278921	78/197 (40%)
		Ion_trans_2	329..411	CDD:285168	32/81 (40%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	370..375		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810