DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shal and KCNQ3

DIOPT Version :9

Sequence 1:NP_001097646.1 Gene:Shal / 40129 FlyBaseID:FBgn0005564 Length:571 Species:Drosophila melanogaster
Sequence 2:NP_004510.1 Gene:KCNQ3 / 3786 HGNCID:6297 Length:872 Species:Homo sapiens


Alignment Length:380 Identity:88/380 - (23%)
Similarity:154/380 - (40%) Gaps:105/380 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   142 RENAER--------LMDDKLSENGDQNLQQLTNMRQKMWRAFENP-------HTSTSALVFYYVT 191
            |:..:|        |....||....:|..:...::..::.|.|.|       |    ||||..|.
Human    74 RDEGQRRTPQGIGLLAKTPLSRPVKRNNAKYRRIQTLIYDALERPRGWALLYH----ALVFLIVL 134

  Fly   192 G-FFIAVSVMANVVETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAA---- 251
            | ..:||.......|||             .|:    ....|:|..:.||.||:.||::||    
Human   135 GCLILAVLTTFKEYETV-------------SGD----WLLLLETFAIFIFGAEFALRIWAAGCCC 182

  Fly   252 -----PDRCKFVRSVMSIIDV---VAIMPYYIGLGITDNDDVSGAFVTLRVFRVFRIFKFSRHSQ 308
                 ..|.||.|..:.::|:   :|.:| .:.:| ...:.::.:..:||..::.|:.:..|...
Human   183 RYKGWRGRLKFARKPLCMLDIFVLIASVP-VVAVG-NQGNVLATSLRSLRFLQILRMLRMDRRGG 245

  Fly   309 GLRILGYTLKSCASEL------GFLVFSLAMAIIIFATVMFYAEKNVNGTN---------FTSIP 358
            ..::||..:.:.:.||      |||      .:|:.:.:::..||:|...:         |.:..
Human   246 TWKLLGSAICAHSKELITAWYIGFL------TLILSSFLVYLVEKDVPEVDAQGEEMKEEFETYA 304

  Fly   359 AAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFS---RIYHQNQRAD 420
            .|.|:.::|:.|:||||..|:|..|:::....||.||...|||..::.|..:   :..|:.:..:
Human   305 DALWWGLITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHFE 369

  Fly   421 KRKAQRKARLARIRIAKASSGAAFVSKKKAAE---ARW---AAQESGIELDDNYR 469
            ||                        :|.|||   |.|   |...:.|:|...:|
Human   370 KR------------------------RKPAAELIQAAWRYYATNPNRIDLVATWR 400

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShalNP_001097646.1 BTB_POZ_Shal-like 6..144 CDD:349727 1/1 (100%)
Ion_trans 188..415 CDD:395416 61/257 (24%)
DUF3399 445..540 CDD:403174 10/31 (32%)
KCNQ3NP_004510.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..43
Ion_trans 139..363 CDD:278921 59/248 (24%)
Ion_trans_2 269..353 CDD:285168 25/89 (28%)
Selectivity filter. /evidence=ECO:0000250 316..321 3/4 (75%)
Mediates interaction with calmodulin. /evidence=ECO:0000269|PubMed:27564677 356..537 13/69 (19%)
KCNQ_channel 452..656 CDD:281513
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 575..611
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 764..872
KCNQC3-Ank-G_bd 780..866 CDD:288784
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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