| Sequence 1: | NP_001097646.1 | Gene: | Shal / 40129 | FlyBaseID: | FBgn0005564 | Length: | 571 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001017425.2 | Gene: | KCNK2 / 3776 | HGNCID: | 6277 | Length: | 426 | Species: | Homo sapiens |
| Alignment Length: | 256 | Identity: | 54/256 - (21%) |
|---|---|---|---|
| Similarity: | 86/256 - (33%) | Gaps: | 98/256 - (38%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 267 VVAIMPYYIGLGITDND----DVSGAF-------VTLRVFRVF------RIFKFSRHSQGLRILG 314
Fly 315 YTLKSCASELG-------------FLVFSLA---------MAIIIFATVMFYA-----EKNVNGT 352
Fly 353 NFTSIPAAFWYTIVTMTTLGYGDMVPETIAGK----------------IVGGVCSLSGVL----- 396
Fly 397 ---VIALPVPVIVSNFS-----------------------RIYHQNQRADKRKAQRKARLA 431 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Shal | NP_001097646.1 | BTB_POZ_Shal-like | 6..144 | CDD:349727 | |
| Ion_trans | 188..415 | CDD:459842 | 47/238 (20%) | ||
| DUF3399 | 471..535 | CDD:463381 | |||
| KCNK2 | NP_001017425.2 | Important for GNG4 binding and L-glutamate release in astrocytes. /evidence=ECO:0000250|UniProtKB:Q920B6 | 17..38 | ||
| Important for GNG4 binding and L-glutamate release in astrocytes. /evidence=ECO:0000250|UniProtKB:Q920B6 | 51..61 | ||||
| Ion_trans_2 | <138..196 | CDD:462301 | 8/57 (14%) | ||
| Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:Q920B6 | 157..162 | 1/4 (25%) | |||
| Ion_trans_2 | 234..312 | CDD:462301 | 20/84 (24%) | ||
| Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:Q920B6 | 266..271 | 2/4 (50%) | |||
| Interaction with AKAP5. /evidence=ECO:0000250|UniProtKB:P97438 | 313..326 | 3/12 (25%) | |||
| Essential for chloroform and halothane sensitivity. /evidence=ECO:0000250|UniProtKB:P97438 | 337..385 | 9/34 (26%) | |||
| Blue background indicates that the domain is not in the aligned region. | |||||