DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and KCNG1

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_002228.2	Gene:	KCNG1 / 3755	HGNCID:	6248	Length:	513	Species:	Homo sapiens

Alignment Length:	440	Identity:	148/440 - (33%)
Similarity:	227/440 - (51%)	Gaps:	56/440 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 PKDRRKTDDEKLLINVSGRRFETWRNTLEKYPDTLLG-----SNEREFF-----YDEDCKEYFFD 86
            |:|||:    :::|||.|.::.....||:::|.|.||     :|..:..     ||..|.|:|||
Human    58 PEDRRR----RIIINVGGIKYSLPWTTLDEFPLTRLGQLKACTNFDDILNVCDDYDVTCNEFFFD 118

  Fly    87 RDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERL--- 148
            |:|..|..||.:.|.|||...:..|..|:.|||.::||..|.:..||...|..:..|.||.:
Human   119 RNPGAFGTILTFLRAGKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMVERE 183

  Fly   149 -MDDKL------SENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVET 206
             .||.|      ||...:...:|....:::....|.||:.....||..::..|:.|:.:...|.|
Human   184 EEDDALDSEGRDSEGPAEGEGRLGRCMRRLRDMVERPHSGLPGKVFACLSVLFVTVTAVNLSVST 248

  Fly   207 VPC-------GHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSI 264
            :|.       ||         |.:....||. :::.||..|:.|:||||..||.:..|:||.:::
Human   249 LPSLREEEEQGH---------CSQMCHNVFI-VESVCVGWFSLEFLLRLIQAPSKFAFLRSPLTL 303

  Fly   265 IDVVAIMPYYI--------------GLGITDNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGY 315
            ||:|||:||||              |.|.:..|.|......||..|:..:.:.:|||.||:.||.
Human   304 IDLVAILPYYITLLVDGAAAGRRKPGAGNSYLDKVGLVLRVLRALRILYVMRLARHSLGLQTLGL 368

  Fly   316 TLKSCASELGFLVFSLAMAIIIFATVMFYAEKNV-NGTNFTSIPAAFWYTIVTMTTLGYGDMVPE 379
            |.:.|..|.|.|:..|.:||.:||.:::..|..: :...||||||.:|:.::||||:|||||||.
Human   369 TARRCTREFGLLLLFLCVAIALFAPLLYVIENEMADSPEFTSIPACYWWAVITMTTVGYGDMVPR 433

  Fly   380 TIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKAR 429
            :..|::|.....|||:|::|.||..|...|||.|.:.::..:|...|:|:
Human   434 STPGQVVALSSILSGILLMAFPVTSIFHTFSRSYLELKQEQERVMFRRAQ 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	42/121 (35%)
		Ion_trans	188..415	CDD:395416	89/248 (36%)
		DUF3399	445..540	CDD:403174
KCNG1	NP_002228.2	BTB_POZ_KCNG1_2	60..173	CDD:349728	41/116 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..204		5/19 (26%)
		Ion_trans	227..471	CDD:395416	91/253 (36%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	424..429		3/4 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810