DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shal and KCNF1

DIOPT Version :10

Sequence 1:NP_001097646.1 Gene:Shal / 40129 FlyBaseID:FBgn0005564 Length:571 Species:Drosophila melanogaster
Sequence 2:NP_002227.2 Gene:KCNF1 / 3754 HGNCID:6246 Length:494 Species:Homo sapiens


Alignment Length:446 Identity:146/446 - (32%)
Similarity:234/446 - (52%) Gaps:47/446 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 PPPMPKDRRKTDDEKLLINVSGRRFETWRNTLEKYPDT--------LLGSNEREFF----YDEDC 80
            |.|..:....:||.::::||.|.|...:.:.|.:||:|        |.|..:..|.    ||...
Human    10 PEPGSQSSAASDDIEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDDYDPGK 74

  Fly    81 KEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENA 145
            :|::||||||.|:.::..|..|::|..|..|...:..|:.|:.:....:.||| :.:...|||..
Human    75 REFYFDRDPDAFKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCC-KSHLSEKREEL 138

  Fly   146 E------RLMDDKLSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVV 204
            |      :|:.|.|..:..:.  :....::.:|:..|.|.:|..|.|...::...|.||.:...:
Human   139 EEIARRVQLILDDLGVDAAEG--RWRRCQKCVWKFLEKPESSCPARVVAVLSFLLILVSSVVMCM 201

  Fly   205 ETVP-------CGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVM 262
            .|:|       .|:|...    |..|.       ::|||:..||.|||||||::|::..|..|.|
Human   202 GTIPELQVLDAEGNRVEH----PTLEN-------VETACIGWFTLEYLLRLFSSPNKLHFALSFM 255

  Fly   263 SIIDVVAIMPYYIGLGIT-------DNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSC 320
            :|:||:||:|:|:.|.:|       :..:|..|...||:.|:.||||.:|||.||:.|.|.||..
Human   256 NIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALKRS 320

  Fly   321 ASELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKI 385
            ..|||.|:..||:.|.:|:.:.:..|::...|.|.|||.:||:.|:||||:||||:.|:|..||:
Human   321 FKELGLLLMYLAVGIFVFSALGYTMEQSHPETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKL 385

  Fly   386 VGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSG 441
            ...:..|.||:.||||:..|::||.| |:..||..:..|:.:..|..:..:....|
Human   386 NAAISFLCGVIAIALPIHPIINNFVR-YYNKQRVLETAAKHELELMELNSSSGGEG 440

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShalNP_001097646.1 BTB_POZ_Shal-like 6..144 CDD:349727 37/127 (29%)
Ion_trans 188..415 CDD:459842 93/240 (39%)
DUF3399 471..535 CDD:463381
KCNF1NP_002227.2 BTB_POZ_Kv5_KCNF1 23..138 CDD:349690 34/115 (30%)
Ion_trans 181..417 CDD:459842 95/247 (38%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 370..375 3/4 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 433..469 1/8 (13%)
Blue background indicates that the domain is not in the aligned region.

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