DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shal and KCND3

DIOPT Version :9

Sequence 1:NP_001097646.1 Gene:Shal / 40129 FlyBaseID:FBgn0005564 Length:571 Species:Drosophila melanogaster
Sequence 2:NP_001365898.1 Gene:KCND3 / 3752 HGNCID:6239 Length:655 Species:Homo sapiens


Alignment Length:608 Identity:379/608 - (62%)
Similarity:454/608 - (74%) Gaps:56/608 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 ASVAAWLPFARAAAIGWVPIATHPLPPPPMPKDRRKTDDEKLLINVSGRRFETWRNTLEKYPDTL 66
            |.|||||||||||||||:|:|..|:|..|..|::|:  ||.:::|||||||:|||.|||:|||||
Human     3 AGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQ--DELIVLNVSGRRFQTWRTTLERYPDTL 65

  Fly    67 LGSNEREFFYDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGD 131
            |||.|:|||::||.|||||||||::||.:||:|||||||||::||:::||:||||:||:|::|||
Human    66 LGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGD 130

  Fly   132 CCYEDYRDRKRENAERLMDDKLSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIA 196
            ||||:|:|||||||||||||..|||..:::..| :.||.||||||||||||.|||||||||||||
Human   131 CCYEEYKDRKRENAERLMDDNDSENNQESMPSL-SFRQTMWRAFENPHTSTLALVFYYVTGFFIA 194

  Fly   197 VSVMANVVETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSV 261
            |||:.|||||||||..|| :..|||||||.:.|||||||||||||.||||||||||.|.:|:|||
Human   195 VSVITNVVETVPCGTVPG-SKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSV 258

  Fly   262 MSIIDVVAIMPYYIGLGITDNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGF 326
            ||||||||||||||||.:|:|:|||||||||||||||||||||||||||||||||||||||||||
Human   259 MSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGF 323

  Fly   327 LVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCS 391
            |:|||.|||||||||||||||..:.:.||||||:||||||||||||||||||:||||||.|.:||
Human   324 LLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICS 388

  Fly   392 LSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSGAAFVSKKKAAEARWA 456
            |||||||||||||||||||||||||||||||:||:||||||||:||..|..|::..|:......|
Human   389 LSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEA 453

  Fly   457 AQESGIELDDNY-RDEDIFELQHHHLLRCLEKTT------------------------DREFVEL 496
            .:.:|...:::. :...:.|.||||||.||||||                        |.:..|.
Human   454 LELTGTPEEEHMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQ 518

  Fly   497 EIPFNGQPKRPGSPSPMASPAHSTNSAAGLLQSCCGRCCSQ------------RYQAC------- 542
            ....:.....|.:.||      |.:|..||..:||.|...:            |.::.       
Human   519 NCMESSMQNYPSTRSP------SLSSHPGLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIH 577

  Fly   543 --GKYMPAASNAQNSQNNQPMDG 563
              |...|:.:.:::|.|.:..||
Human   578 IQGSEQPSLTTSRSSLNLKADDG 600

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShalNP_001097646.1 BTB_POZ_Shal-like 6..144 CDD:349727 94/137 (69%)
Ion_trans 188..415 CDD:395416 193/226 (85%)
DUF3399 445..540 CDD:403174 29/131 (22%)
KCND3NP_001365898.1 Interaction with KCNIP2. /evidence=ECO:0000250 2..20 15/16 (94%)
BTB_POZ_KCND3 6..143 CDD:349726 95/138 (69%)
Ion_trans 186..412 CDD:395416 193/226 (85%)
Selectivity filter. /evidence=ECO:0000250 367..372 4/4 (100%)
DUF3399 442..563 CDD:403174 28/126 (22%)
Mediates dendritic targeting. /evidence=ECO:0000250 472..487 11/14 (79%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 525..565 10/45 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 615..655
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158828
Domainoid 1 1.000 402 1.000 Domainoid score I731
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 757 1.000 Inparanoid score I557
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48930
OrthoDB 1 1.010 - - D221939at33208
OrthoFinder 1 1.000 - - FOG0001867
OrthoInspector 1 1.000 - - otm41431
orthoMCL 1 0.900 - - OOG6_103639
Panther 1 1.100 - - LDO PTHR11537
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4179
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.800

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