Protein Alignment Shal and KCNC2

DIOPT Version :9

• Sequence 1: NP_001097646.1
• Gene: Shal / 40129
• FlyBaseID: FBgn0005564
• Length: 571
• Species: Drosophila melanogaster
• Sequence 2: NP_631875.1
• Gene: KCNC2 / 3747
• HGNCID: 6234
• Length: 638
• Species: Homo sapiens
• Alignment Length: 585
• Identity: 179/585 - (30%)
• Similarity: 277/585 - (47%)
• Gaps: 142/585 - (24%)

  Fly    39 DDEKLLINVSGRRFETWRNTLEKYPDT---LLGSNEREFFYDEDC-------------------- 80
            ::|::::||.|.|.||:|:||:..|.|   ||.|:|.    ..||
Human     6 NNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEP----PGDCLTTAGDKLQPSPPPLSPPPR 66

  Fly    81 ---------------------------------KEYFFDRDPDIFRHILNYYRTGKLHYPKHECL 112
                                             :|:||||.|.:|.::||||||||||.|...|.
Human    67 APPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADVCG 131

  Fly   113 TSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMD--------------------------D 151
            ..::|||||:||....:..||:..||..:  :||..:|                          |
Human   132 PLFEEELAFWGIDETDVEPCCWMTYRQHR--DAEEALDIFETPDLIGGDPGDDEDLAAKRLGIED 194

  Fly   152 KLSENG-DQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVET------VPC 209
            .....| |....:...::.:||..||:|::|.:|....:.:.|||.||:....:||      |..
Human   195 AAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKN 259

  Fly   210 GHRPGRAGTLPCGERYKI----VFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAI 270
            ...|...|| ....:|:|    ....::..||:.||.|:|:|:..:|::.:|::::::|||.|||
Human   260 KTEPVINGT-SVVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAI 323

  Fly   271 MPYYIGLGITD-----NDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLVFS 330
            :|:|:.:|::.     ..||.|....:|..|:.||||.:||..|||:||:||::..:|...|:..
Human   324 LPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIF 388

  Fly   331 LAMAIIIFATVMFYAEK---------NVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIV 386
            ||:.::||||:::|||:         ....|.|.:||..||:.:|||||||||||.|:|.:|.:|
Human   389 LALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLV 453

  Fly   387 GGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSGAAFVSKKKAA 451
            |.:|:|:|||.||:||||||:||...|  :....|:|..|| |...|..|..:|...|..    .
Human   454 GALCALAGVLTIAMPVPVIVNNFGMYY--SLAMAKQKLPRK-RKKHIPPAPQASSPTFCK----T 511

  Fly   452 EARWAAQESGIELDDNYRDEDIFELQHHHLLRCLEKTTDREFVELEIPFNGQPKRPGSPSPMASP 516
            |...|...:   ..|....:|...|:|:..:...:.:|                  ||..|::.|
Human   512 ELNMACNST---QSDTCLGKDNRLLEHNRSVLSGDDST------------------GSEPPLSPP 555

  Fly   517  516
            Human   556  555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	48/160 (30%)
		Ion_trans	188..415	CDD:395416	98/250 (39%)
		DUF3399	445..540	CDD:403174	11/72 (15%)
KCNC2	NP_631875.1	BTB_KCNC2_4	7..166	CDD:349722	50/164 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	38..93		4/58 (7%)
		Ion_trans	228..484	CDD:395416	99/258 (38%)
		Selectivity filter. /evidence=ECO:0000250	437..442		4/4 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	538..572		5/36 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810