Protein Alignment Shal and KCNC1

DIOPT Version :10

• Sequence 1: NP_001097646.1
• Gene: Shal / 40129
• FlyBaseID: FBgn0005564
• Length: 571
• Species: Drosophila melanogaster
• Sequence 2: NP_001106212.1
• Gene: KCNC1 / 3746
• HGNCID: 6233
• Length: 585
• Species: Homo sapiens
• Alignment Length: 598
• Identity: 185/598 - (30%)
• Similarity: 288/598 - (48%)
• Gaps: 114/598 - (19%)

  Fly    39 DDEKLLINVSGRRFETWRNTLEKYPDTLLG-----SNEREFFYDEDCKEYFFDRDPDIFRHILNY 98
            :.|:::|||.|.|.:|:|:||...|.|.|.     .....|.||....|:||||.|.:|.|||||
Human     6 ESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNY 70

  Fly    99 YRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMD------------- 150
            |||||||.|...|...|:|||||:||....:..||:..||..:  :||..:|
Human    71 YRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHR--DAEEALDSFGGAPLDNSADD 133

  Fly   151 ---DKLSENGD-QNLQQLT------------------NMRQKMWRAFENPHTSTSALVFYYVTGF 193
               |...::|| ::..::|                  ..:.::|..||:|::|..|....:.:.|
Human   134 ADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLF 198

  Fly   194 FIAVSVMANVVET----VPCGHRPG----RAGTLPCGERY------KIVFFCLDTACVMIFTAEY 244
            ||.||:....:||    .|..::..    |.||   ..||      :.....::..||:.||.|:
Human   199 FILVSITTFCLETHERFNPIVNKTEIENVRNGT---QVRYYREAETEAFLTYIEGVCVVWFTFEF 260

  Fly   245 LLRLFAAPDRCKFVRSVMSIIDVVAIMPYYIGLGITD-----NDDVSGAFVTLRVFRVFRIFKFS 304
            |:|:...|::.:|:::.::|||.|||:|:|:.:|::.     ..||.|....:|..|:.||||.:
Human   261 LMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLT 325

  Fly   305 RHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATVMFYAEK---------NVNGTNFTSIPAA 360
            ||..|||:||:||::..:|...|:..||:.::||||:::|||:         ....|:|.:||..
Human   326 RHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIG 390

  Fly   361 FWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQ 425
            ||:.:|||||||||||.|:|.:|.:||.:|:|:|||.||:||||||:||...|.......|...:
Human   391 FWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKK 455

  Fly   426 RKARLARIRIAKASSGAAFVSKKKAAEARWAAQESGIELDDNYRDEDIFELQH------------ 478
            :|..:.|    ....|:....|........:.|.....|    ..|:|.|:..
Human   456 KKKHIPR----PPQLGSPNYCKSVVNSPHHSTQSDTCPL----AQEEILEINRADSKLNGEVAKA 512

  Fly   479 -------HHLLRCLEKTTDREFVELEIPF--NGQPKRPGSPSPMASPAHSTNSAAGLLQSCCGRC 534
                   .|:.:.|  |.|.     .:||  :|..:|.|....:::..::.....|:.:..|
Human   513 ALANEDCPHIDQAL--TPDE-----GLPFTRSGTRERYGPCFLLSTGEYACPPGGGMRKDLC--- 567

  Fly   535 CSQRYQACGKYMP 547
              :......||||
Human   568 --KESPVIAKYMP 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	49/109 (45%)
		Ion_trans	188..415	CDD:459842	98/254 (39%)
		DUF3399	471..535	CDD:463381	14/84 (17%)
KCNC1	NP_001106212.1	BTB_KCNC1_3	6..122	CDD:349721	52/117 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..147		3/25 (12%)
		Ion_trans	189..447	CDD:459842	99/260 (38%)
		Selectivity filter. /evidence=ECO:0000250	400..405		4/4 (100%)