DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shal and KCNB1

DIOPT Version :9

Sequence 1:NP_001097646.1 Gene:Shal / 40129 FlyBaseID:FBgn0005564 Length:571 Species:Drosophila melanogaster
Sequence 2:NP_004966.1 Gene:KCNB1 / 3745 HGNCID:6231 Length:858 Species:Homo sapiens


Alignment Length:533 Identity:187/533 - (35%)
Similarity:283/533 - (53%) Gaps:57/533 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 ATHPLPPPPMPKDRRKTDDEKLLINVSGRRFET-WRNTLEKYPDTLLGS----NEREFF------ 75
            :|..|||.||...|.|....::.:||.|...|. || ||::.|.|.||.    |..:..      
Human    12 STSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWR-TLDRLPRTRLGKLRDCNTHDSLLEVCDD 75

  Fly    76 YDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDR 140
            |..|..||||||.|..|..|||:||||:||..:..|..|:.:||.::||....:..||...|..:
Human    76 YSLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQK 140

  Fly   141 KRENAERL------MDDKLSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSV 199
            |.:..|.|      :.::..|..|...  ....|:|:|...|.|::|.:|.:...::..||.:|.
Human   141 K
EQMNEELKREAETLREREGEEFDNTC--CAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLST 203

  Fly   200 MANVVETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSI 264
            :|..:.|:|........|......:...|    :..|:..||.|||||..::|.:.||.:..::.
Human   204 IALSLNTLPELQSLDEFGQSTDNPQLAHV----EAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNA 264

  Fly   265 IDVVAIMPYYIGLGITDND-------DVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCAS 322
            ||::||:|||:.:.:|:::       :|.......|:.|:.||.|.:|||.||:.||:||:...:
Human   265 IDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYN 329

  Fly   323 ELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVG 387
            |||.|:..|||.|:||::::|:|||:.:.|.|.||||:||:..:||||:||||:.|:|:.|||||
Human   330 ELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVG 394

  Fly   388 GVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSGAAFVS-KKKAA 451
            |:|.::||||||||:|:||:|||..|.:.:|.:|...:|:|      :.:|....:.|| ..|.|
Human   395 GLCCIAGVLVIALPIPIIVNNFSEFYKEQK
RQEKAIKRREA------LERAKRNGSIVSMNMKDA 453

  Fly   452 EARWAAQESGIELDD--------NYRDEDIFELQHHHLLRCLEKTTDREFVELEIPFNGQPKRPG 508
            .||      .||:.|        |...:|  ::|.:||.....|.|.|...|.....:.:.|..|
Human   454 FAR------SIEMMDIVVEKNGENMGKKD--KVQDNHLSPNKWKWTKRTLSETSSSKSFETKEQG 510

  Fly   509 SPS---PMASPAH 518
            ||.   ..:||.|
Human   511 SPEKARSSSSPQH 523

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShalNP_001097646.1 BTB_POZ_Shal-like 6..144 CDD:349727 50/132 (38%)
Ion_trans 188..415 CDD:395416 96/233 (41%)
DUF3399 445..540 CDD:403174 25/86 (29%)
KCNB1NP_004966.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 4/8 (50%)
BTB_POZ_KCNB2 15..141 CDD:349719 48/126 (38%)
Self-association. /evidence=ECO:0000250|UniProtKB:P15387 59..75 1/15 (7%)
Ion_trans 188..424 CDD:395416 97/239 (41%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 377..382 3/4 (75%)
Self-association. /evidence=ECO:0000250|UniProtKB:P15387 448..481 10/40 (25%)
Kv2channel 467..679 CDD:397541 16/59 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 471..524 16/55 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 538..574
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 770..807
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 836..858
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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