DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and KCNA7

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_114092.2	Gene:	KCNA7 / 3743	HGNCID:	6226	Length:	456	Species:	Homo sapiens

Alignment Length:	433	Identity:	164/433 - (37%)
Similarity:	241/433 - (55%)	Gaps:	62/433 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PLPPPPMPKDRRKTDDEKLLINVSGRRFETWRNTLEKYPDTLLGSNERE-FFYDEDCKEYFFDRD 88
            |..|||.      ...|:|::||:|.||||...||.::||||||...|. .|||:..:||||||.
Human     3 PRCPPPC------GCCERLVLNVAGLRFETRARTLGRFPDTLLGDPARRGRFYDDARREYFFDRH 61

  Fly    89 PDIFRHILNYYRT-GKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDK 152
            ...|..:|.||:: |:|..|.|..|..:.||:||:|:....:.         |.||      |:.
Human    62 RPSFDAVLYYYQSGGRLRRPAHVPLDVFLEEVAFYGLGAAALA---------RLRE------DEG 111

  Fly   153 LSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVP--------- 208
            .....::.|.:....|| :|..||.|.:|.:|.|...|:...|.||::...:||:|
Human   112 CPVPPERPLPRRAFARQ-LWLLFEFPESSQAARVLAVVSVLVILVSIVVFCLETLPDFRDDRDGT 175

  Fly   209 -----------------CGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCK 256
                             ....||....||    :...||.::|.|:..|:.|.|:||...|.:..
Human   176 GLAAAAAAGPFPAPLNGSSQMPGNPPRLP----FNDPFFVVETLCICWFSFELLVRLLVCPSKAI 236

  Fly   257 FVRSVMSIIDVVAIMPYYIGLGI-------TDNDDVSGAFV-TLRVFRVFRIFKFSRHSQGLRIL 313
            |.::||::||.|||:||::.||.       .....:|.|.: .:|:.|||||||.||||:||:||
Human   237 FFKNVMNLIDFVAILPYFVALGTELARQRGVGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQIL 301

  Fly   314 GYTLKSCASELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVP 378
            |.||::...|||.|:|.|.:.:::|::.:::||.:...::|||||.:||:.:|||||:|||||.|
Human   302 GQTLRASMRELGLLIFFLFIGVVLFSSAVYFAEVDRVDSHFTSIPESFWWAVVTMTTVGYGDMAP 366

  Fly   379 ETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADK 421
            .|:.|||||.:|:::|||.|:|||||||||||..||:....::
Human   367 VTVGGKIVGSLCAIAGVLTISLPVPVIVSNFSYFYHRETEGEE 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	47/120 (39%)
		Ion_trans	188..415	CDD:395416	104/260 (40%)
		DUF3399	445..540	CDD:403174
KCNA7	NP_114092.2	BTB_2	15..105	CDD:280393	40/98 (41%)
		BTB	15..98	CDD:197585	39/82 (48%)
		Ion_trans	200..404	CDD:278921	96/207 (46%)
		Ion_trans_2	319..398	CDD:285168	42/78 (54%)
		Selectivity filter. /evidence=ECO:0000250	358..363		3/4 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810