DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and KCNA6

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_002226.1	Gene:	KCNA6 / 3742	HGNCID:	6225	Length:	529	Species:	Homo sapiens

Alignment Length:	449	Identity:	161/449 - (35%)
Similarity:	237/449 - (52%)	Gaps:	82/449 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EKLLINVSGRRFETWRNTLEKYPDTLLGS-NEREFFYDEDCKEYFFDRDPDIFRHILNYYRT-GK 103
            |:|:||:||.||||...||..:||||||. ..|..|:|....||||||:...|..||.||:: |:
Human    41 ERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGR 105

  Fly   104 LHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDKLSENGDQNLQQLTN-- 166
            |..|.:..|..:.||:.|:     .:||.....:|:          |:.....|.::.:.|.:
Human   106 LRRPVNVPLDIFLEEIRFY-----QLGDEALAAFRE----------DEGCLPEGGEDEKPLPSQP 155

  Fly   167 MRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVP----------------------- 208
            .::::|..||.|.:|..|.....|:...|.:|::...:||:|
Human   156 FQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRG 220

  Fly   209 ---------------CGHRPGRAGT-------LPCGERYKIVFFCLDTACVMIFTAEYLLRLFAA 251
                           .|..||..||       ...|..:...||.::|.|::.||.|.|:|..|.
Human   221 SQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSAC 285

  Fly   252 PDRCKFVRSVMSIIDVVAIMPYYIGLGI-----TDNDDVSGA-------------FVTLRVFRVF 298
            |.:..|.|::|:|||:|||.||:|.||.     .:....||.             ...:|:.|||
Human   286 PSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVF 350

  Fly   299 RIFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWY 363
            ||||.||||:||:|||.||::...|||.|:|.|.:.:|:|::.:::||.:.:.:.|.|||.|||:
Human   351 RIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWW 415

  Fly   364 TIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKR 422
            .:|||||:|||||.|.|:.|||||.:|:::|||.||||||||||||:..||:....:::
Human   416 AVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQ 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	42/104 (40%)
		Ion_trans	188..415	CDD:395416	109/289 (38%)
		DUF3399	445..540	CDD:403174
KCNA6	NP_002226.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		BTB_POZ_KCNA6	41..170	CDD:349714	49/143 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	210..233		0/22 (0%)
		Ion_trans	258..468	CDD:366146	98/209 (47%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	360..373		7/12 (58%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	422..427		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	488..513
		PDZ-binding. /evidence=ECO:0000255	527..529
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810