DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shal and KCNA5

DIOPT Version :9

Sequence 1:NP_001097646.1 Gene:Shal / 40129 FlyBaseID:FBgn0005564 Length:571 Species:Drosophila melanogaster
Sequence 2:NP_002225.2 Gene:KCNA5 / 3741 HGNCID:6224 Length:613 Species:Homo sapiens


Alignment Length:560 Identity:188/560 - (33%)
Similarity:279/560 - (49%) Gaps:118/560 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 PLPPPP--MPKDRR--KTDDE-----------------------KLLINVSGRRFETWRNTLEKY 62
            ||||.|  :|:.||  ..|:|                       ::.||:||.||||...||.::
Human    77 PLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQF 141

  Fly    63 PDTLLGSNEREF-FYDEDCKEYFFDRDPDIFRHILNYYRT-GKLHYPKHECLTSYDEELAFFGIM 125
            |:||||...:.. ::|....||||||:...|..||.||:: |:|..|.:..|..:.:|:.|:   
Human   142 PNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFY--- 203

  Fly   126 PDVIGDCCYEDYRDRKRENAERLMDDKLSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYV 190
              .:||...|.:|:          |:...:..::.|.: ...::::|..||.|.:|.||.....|
Human   204 --QLGDEAMERF
RE----------DEGFIKEEEKPLPR-NEFQRQVWLIFEYPESSGSARAIAIV 255

  Fly   191 TGFFIAVSVMANVVETV-------------PCGHR-----PGRAGT----LPCGERYKIV----- 228
            :...|.:|::...:||:             |..|:     ||..|:    .|.|.....:     
Human   256 SVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTL 320

  Fly   229 ---FFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIMPYYIGLGIT---------- 280
               ||.::|.||:.||.|.|:|.||.|.:..|.|::|:|||||||.||:|.||..          
Human   321 ADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGG 385

  Fly   281 --DNDDVSGAFVTLRVF---RVFRIFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFAT 340
              .|...:.:...|||.   |||||||.||||:||:|||.||::...|||.|:|.|.:.:|:|::
Human   386 GGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSS 450

  Fly   341 VMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVI 405
            .:::||.:..||:|:|||.|||:.:|||||:|||||.|.|:.|||||.:|:::|||.||||||||
Human   451 AVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVI 515

  Fly   406 VSNFSRIYHQNQRADK------------------RKAQRKARLARIRIAKASSGAAFVSKKKAAE 452
            ||||:..||:....::                  |..|||...:|....||  |....:...|..
Human   516 VSNFNYFYHRE
TDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKA--GGTLENADSARR 578

  Fly   453 ARWAAQESGIELDDNYRDEDIFELQHHHLLRCLEKTTDRE 492
            .....::..::...|      .:|:......||:  |.||
Human   579 GSCPLEKCNVKAKSN------VDLRRSLYALCLD--TSRE 610

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShalNP_001097646.1 BTB_POZ_Shal-like 6..144 CDD:349727 47/147 (32%)
Ion_trans 188..415 CDD:395416 115/271 (42%)
DUF3399 445..540 CDD:403174 8/48 (17%)
KCNA5NP_002225.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..108 10/30 (33%)
2 X 11 AA tandem repeat of D-[SP]-G-V-R-P-L-P-P-L-P 61..82 4/4 (100%)
BTB_2 122..213 CDD:308049 36/95 (38%)
Ion_trans 249..526 CDD:306908 117/276 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 282..304 5/21 (24%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 418..431 7/12 (58%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 480..485 3/4 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..559 4/26 (15%)
PDZ-binding. /evidence=ECO:0000250 611..613 188/560 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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