Protein Alignment Shal and KCNA4

DIOPT Version :10

• Sequence 1: NP_001097646.1
• Gene: Shal / 40129
• FlyBaseID: FBgn0005564
• Length: 571
• Species: Drosophila melanogaster
• Sequence 2: NP_002224.1
• Gene: KCNA4 / 3739
• HGNCID: 6222
• Length: 653
• Species: Homo sapiens
• Alignment Length: 471
• Identity: 167/471 - (35%)
• Similarity: 263/471 - (55%)
• Gaps: 76/471 - (16%)

  Fly    41 EKLLINVSGRRFETWRNTLEKYPDTLLGSNE-REFFYDEDCKEYFFDRDPDIFRHILNYYRT-GK 103
            |:::|||||.||||...||.::|:||||..| |..::|....||||||:...|..||.||:: |:
Human   176 ERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGR 240

  Fly   104 LHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDK-LSENGDQNLQQLTNM 167
            |..|.:.....:.||:.|:.:..:.:       .:.|:.|...|..:|: |.||         ..
Human   241 LKRPVNVPFDIFTEEVKFYQLGEEAL-------LKFREDEGFVREEEDRALPEN---------EF 289

  Fly   168 RQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVP-------------CGHRPGRAGTL 219
            ::::|..||.|.:|:.|.....|:...|.:|::...:||:|             .|   |..|.|
Human   290 KKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAG---GHGGLL 351

  Fly   220 -----PCGER-----YKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIMPYY 274
                 |..|.     :...||.::|.|::.|:.|:::|.||.|.:..|.:::|:|||:|:|:||:
Human   352 NDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYF 416

  Fly   275 IGLGITDNDDVSG----------AFVTLRVF---RVFRIFKFSRHSQGLRILGYTLKSCASELGF 326
            |.|| ||.....|          :|..||:.   |||||||.||||:||:|||:||::...|||.
Human   417 ITLG-TDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGL 480

  Fly   327 LVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCS 391
            |:|.|.:.:|:|::.:::||.:...|:|.|||.|||:.:|||||:|||||.|.|:.|||||.:|:
Human   481 LIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCA 545

  Fly   392 LSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIA------------KASSGAAF 444
            ::|||.||||||||||||:..||:     :.:.:.:.:|.:..::            ::|:.::.
Human   546 IAGVLTIALPVPVIVSNFNYFYHR-----ETENEEQTQLTQNAVSCPYLPSNLLKKFRSSTSSSL 605

  Fly   445 VSKKKAAEARWAAQES 460
            ..|.:..|.....:||
Human   606 GDKSEYLEMEEGVKES 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	38/104 (37%)
		Ion_trans	188..415	CDD:459842	110/262 (42%)
		DUF3399	471..535	CDD:463381
KCNA4	NP_002224.1	K_channel_TID	1..>37	CDD:429748
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..148
		BTB_POZ	176..303	CDD:453885	48/142 (34%)
		Ion_trans	306..570	CDD:459842	112/272 (41%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	462..475		7/12 (58%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	524..529		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	629..653
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:P15385	651..653