Protein Alignment Shal and KCNA3

DIOPT Version :10

• Sequence 1: NP_001097646.1
• Gene: Shal / 40129
• FlyBaseID: FBgn0005564
• Length: 571
• Species: Drosophila melanogaster
• Sequence 2: NP_002223.3
• Gene: KCNA3 / 3738
• HGNCID: 6221
• Length: 575
• Species: Homo sapiens
• Alignment Length: 456
• Identity: 166/456 - (36%)
• Similarity: 251/456 - (55%)
• Gaps: 65/456 - (14%)

  Fly    25 PLPPPPMPKDRRKTDDEKLLINVSGRRFETWRNTLEKYPDTLLGSNEREF-FYDEDCKEYFFDRD 88
            ||||.......:....|:::||:||.||||...||.::|:||||..:|.. ::|....||||||:
Human    88 PLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRN 152

  Fly    89 PDIFRHILNYYRT-GKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDK 152
            ...|..||.||:: |::..|.:..:..:.||:.|:     .:|:...|.:|:          |:.
Human   153 RPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFY-----QLGEEAMEKFRE----------DEG 202

  Fly   153 LSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVPCGHRPGR-- 215
            .....::.|.:....|| :|..||.|.:|..|.....|:...|.:|::...:||:| ..|..:
Human   203 FLREEERPLPRRDFQRQ-VWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLP-EFRDEKDY 265

  Fly   216 -----------AGTLPCGER-----YKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSI 264
                       ||....|.|     :...||.::|.|::.|:.|.|:|.||.|.:..|.|::|::
Human   266 PASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNL 330

  Fly   265 IDVVAIMPYYIGLGI-----TDNDDVSGAFVTLRVF---RVFRIFKFSRHSQGLRILGYTLKSCA 321
            ||:|||:||:|.||.     ..|...:.:...|||.   |||||||.||||:||:|||.|||:..
Human   331 IDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASM 395

  Fly   322 SELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIV 386
            .|||.|:|.|.:.:|:|::.:::||.:...:.|:|||.|||:.:|||||:|||||.|.||.||||
Human   396 RELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIV 460

  Fly   387 GGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADK--------------------RKAQRKARLA 431
            |.:|:::|||.||||||||||||:..||:....::                    |||:..:.|:
Human   461 GSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLS 525

  Fly   432 R 432
            :
Human   526 K 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	41/120 (34%)
		Ion_trans	188..415	CDD:459842	110/252 (44%)
		DUF3399	471..535	CDD:463381
KCNA3	NP_002223.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52
		BTB_POZ	104..230	CDD:453885	45/141 (32%)
		Ion_trans	233..490	CDD:459842	112/257 (44%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	444..449		3/4 (75%)
		Interaction with KCNE4. /evidence=ECO:0000250|UniProtKB:P15384	482..575		8/45 (18%)
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:P15384	573..575