DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and KCNA3

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_002223.3	Gene:	KCNA3 / 3738	HGNCID:	6221	Length:	575	Species:	Homo sapiens

Alignment Length:	456	Identity:	166/456 - (36%)
Similarity:	251/456 - (55%)	Gaps:	65/456 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PLPPPPMPKDRRKTDDEKLLINVSGRRFETWRNTLEKYPDTLLGSNEREF-FYDEDCKEYFFDRD 88
            ||||.......:....|:::||:||.||||...||.::|:||||..:|.. ::|....||||||:
Human    88 PLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRN 152

  Fly    89 PDIFRHILNYYRT-GKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDK 152
            ...|..||.||:: |::..|.:..:..:.||:.|:     .:|:...|.:|:          |:.
Human   153 RPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFY-----QLGEEAMEKFRE----------DEG 202

  Fly   153 LSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVPCGHRPGR-- 215
            .....::.|.:....|| :|..||.|.:|..|.....|:...|.:|::...:||:| ..|..:
Human   203 FLREEERPLPRRDFQRQ-VWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLP-EFRDEKDY 265

  Fly   216 -----------AGTLPCGER-----YKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSI 264
                       ||....|.|     :...||.::|.|::.|:.|.|:|.||.|.:..|.|::|::
Human   266 PASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNL 330

  Fly   265 IDVVAIMPYYIGLGI-----TDNDDVSGAFVTLRVF---RVFRIFKFSRHSQGLRILGYTLKSCA 321
            ||:|||:||:|.||.     ..|...:.:...|||.   |||||||.||||:||:|||.|||:..
Human   331 IDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASM 395

  Fly   322 SELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIV 386
            .|||.|:|.|.:.:|:|::.:::||.:...:.|:|||.|||:.:|||||:|||||.|.||.||||
Human   396 RELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIV 460

  Fly   387 GGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADK--------------------RKAQRKARLA 431
            |.:|:::|||.||||||||||||:..||:....::                    |||:..:.|:
Human   461 GSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLS 525

  Fly   432 R 432
            :
Human   526 K 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	41/120 (34%)
		Ion_trans	188..415	CDD:395416	110/252 (44%)
		DUF3399	445..540	CDD:403174
KCNA3	NP_002223.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		BTB	106..200	CDD:197585	36/108 (33%)
		BTB_2	106..197	CDD:280393	35/95 (37%)
		Ion_trans	290..490	CDD:278921	100/199 (50%)
		Ion_trans_2	404..481	CDD:285168	42/76 (55%)
		Selectivity filter. /evidence=ECO:0000250	444..449		3/4 (75%)
		PDZ-binding. /evidence=ECO:0000250	573..575
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810