DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shal and Shaw

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	184/549 - (33%)
Similarity:	288/549 - (52%)	Gaps:	59/549 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 DEKLLINVSGRRFETWRNTLEKYPDTLLGS-NEREFFYDEDCKEYFFDRDPDIFRHILNYYRTGK 103
            :.::::||.|.|.||::.||:|.|.|.|.. .|....||....||||||.|.:|..:||||||||
  Fly    24 ENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRTGK 88

  Fly   104 LHYPKHECLTSYDEELAFFGIMPDVIGDCC---YEDYRDRKRENA--ERL-MD-DKLSENG---- 157
            ||||...|...::|||.|:|:..:.:..||   |..:||.:...|  :|| :| :|.||..
  Fly    89 LHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEELARK 153

  Fly   158 ---DQNLQQLT-----NMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVPCGHRP- 213
               :::..:.|     .|:.::|..|:.|::|.:|.....|:.|||.:|:::..::|.|....|
  Fly   154 FGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPDMRVPI 218

  Fly   214 ----------GRAGTL--PCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIID 266
                      |..|..  .......|.||.::..|...||.|.|:|..::|::.:|::|.::|||
  Fly   219 VRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEFIKSSVNIID 283

  Fly   267 VVAIMPYYIGLGI------TDNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELG 325
            .:|.:.:||.|.:      .:|.|:...|   .:.|:.|:||.:|||.||:||..|.::.|.||.
  Fly   284 YIATLSFYIDLVLQRFASHLENADILEFF---SIIRIMRLFKLTRHSSGLKILIQTFRASAKELT 345

  Fly   326 FLVFSLAMAIIIFATVMFYAEK-NVNGTN-FTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGG 388
            .|||.|.:.|:|||::::|||: ..|..| |.|||...|:.:|||||:|||||.|:|..|..||.
  Fly   346 LLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGA 410

  Fly   389 VCSLSGVLVIALPVPVIVSNFSRIY-HQNQRADKRKAQRKA----RLARIRIAKASSGAAFVSKK 448
            :|:|:|||.||||||||||||:..| |...||...|.:|:.    :..:.|:..|..|.:.....
  Fly   411 LCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVLPVEQPRQPRLPGAPGGVSGCGTP 475

  Fly   449 KAAEARWAAQESGI---ELDDNYRD----EDIFELQHHHLLRCLEKTTDREFVELEIPF-NGQPK 505
            .:..........|.   .:::..:|    :.:.:|....|...:...:.|..::|.... .|:|.
  Fly   476 GSGPHSGPMGSGGTGPRRMNNKTKDLVSPKSVAQLFAGPLGASIVAMSPRTMLDLNPALAMGKPT 540

  Fly   506 -RPGSPSPM-ASPAHSTNSAAGLLQSCCG 532
             :|..|:|: |:|....:||.|:..|..|
  Fly   541 FQPRIPTPLAATPPPPVSSAGGMTASGIG 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	46/107 (43%)
		Ion_trans	188..415	CDD:395416	98/248 (40%)
		DUF3399	445..540	CDD:403174	18/98 (18%)
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	44/97 (45%)
		BTB_2	27..117	CDD:280393	41/89 (46%)
		Ion_trans	244..439	CDD:278921	89/197 (45%)
		Ion_trans_2	355..429	CDD:285168	42/73 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
	4	3.910