DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and Kcna10

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_001178642.1	Gene:	Kcna10 / 295360	RGDID:	1304667	Length:	511	Species:	Rattus norvegicus

Alignment Length:	449	Identity:	153/449 - (34%)
Similarity:	257/449 - (57%)	Gaps:	52/449 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 DEKLLINVSGRRFETWRNTLEKYPDTLLGSNEREF-FYDEDCKEYFFDRDPDIFRHILNYYRT-G 102
            :::::||::|.||||...||.::|:||||..|:.. |:|....||||||:...|..||.||:: |
  Rat    85 NQRVIINIAGLRFETQLRTLNQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGG 149

  Fly   103 KLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDKLSENGDQNLQQLTNM 167
            |:..|.:..:..:.:|::|:.:..:.:         |:.||:...:.|       .:.|....:.
  Rat   150 KIRRPANVPIDVFADEISFYELGSEAM---------DQFREDEGFIKD-------PETLLPTNDF 198

  Fly   168 RQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVP----------------CGHRPGRA 216
            .::.|..||.|.:|::|.....|:...:.:|:....:||:|                ..::.|.:
  Rat   199 HRQFWLLFEYPESSSAARGVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPTINTNKTGLS 263

  Fly   217 GTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIMPYYIGLGITD 281
            .|:     :...||.:::.|::.||.|.:||....|.:..|.:::|:|||:::|:||:..| ||:
  Rat   264 QTM-----FTDPFFMVESTCIVWFTFELVLRFVVCPSKPDFFKNIMNIIDIISIIPYFATL-ITE 322

  Fly   282 ---------NDDVSGAFV-TLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAII 336
                     ..::|.|.: .:|:.|||||||.||||:||:|||.|||:...|||.|:|.|.:.:|
  Rat   323 LVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVI 387

  Fly   337 IFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALP 401
            :|::.:::||.:...::|:|||..||:.:|||||:|||||.|.|..|||||.:|:::|||.||||
  Rat   388 LFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALP 452

  Fly   402 VPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSGAAFVSKKKAAEARWAAQES 460
            ||||||||:..||: :..::.|......|.:|..:..|...:..|..|...:| :|::|
  Rat   453 VPVIVSNFNYFYHR-ETENEEKPNIPGELDKILNSMGSRTGSTESLNKTNSSR-SAEKS 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	35/105 (33%)
		Ion_trans	188..415	CDD:395416	99/252 (39%)
		DUF3399	445..540	CDD:403174	5/16 (31%)
Kcna10	NP_001178642.1	BTB_2	88..179	CDD:280393	34/99 (34%)
		BTB	88..171	CDD:197585	33/82 (40%)
		Ion_trans	267..467	CDD:278921	93/201 (46%)
		Ion_trans_2	382..458	CDD:285168	40/75 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810