DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shal and Kcnb1

DIOPT Version :9

Sequence 1:NP_001097646.1 Gene:Shal / 40129 FlyBaseID:FBgn0005564 Length:571 Species:Drosophila melanogaster
Sequence 2:NP_037318.2 Gene:Kcnb1 / 25736 RGDID:2954 Length:857 Species:Rattus norvegicus


Alignment Length:531 Identity:186/531 - (35%)
Similarity:282/531 - (53%) Gaps:53/531 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 ATHPLPPPPMPKDRRKTDDEKLLINVSGRRFET-WRNTLEKYPDTLLGS----NEREFF------ 75
            :|..|||.||...|.|....::.:||.|...|. || ||::.|.|.||.    |..:..      
  Rat    12 STSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWR-TLDRLPRTRLGKLRDCNTHDSLLQVCDD 75

  Fly    76 YDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDR 140
            |..:..||||||.|..|..|||:||||:||..:..|..|:.:||.::||....:..||...|..:
  Rat    76 YSLEDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQK 140

  Fly   141 KRENAERL------MDDKLSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSV 199
            |.:..|.|      :.::..|..|...  ....|:|:|...|.|::|.:|.:...::..||.:|.
  Rat   141 K
EQMNEELKREAETLREREGEEFDNTC--CAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLST 203

  Fly   200 MANVVETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSI 264
            :|..:.|:|........|......:...|    :..|:..||.|||||..::|.:.||.:..::.
  Rat   204 IALSLNTLPELQSLDEFGQSTDNPQLAHV----EAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNA 264

  Fly   265 IDVVAIMPYYIGLGITDND-------DVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCAS 322
            ||::||:|||:.:.:|:::       :|.......|:.|:.||.|.:|||.||:.||:||:...:
  Rat   265 IDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYN 329

  Fly   323 ELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVG 387
            |||.|:..|||.|:||::::|:|||:.:.|.|.||||:||:..:||||:||||:.|:|:.|||||
  Rat   330 ELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVG 394

  Fly   388 GVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSGAAFVS-KKKAA 451
            |:|.::||||||||:|:||:|||..|.:.:|.:|...:|:|      :.:|....:.|| ..|.|
  Rat   395 GLCCIAGVLVIALPIPIIVNNFSEFYKEQK
RQEKAIKRREA------LERAKRNGSIVSMNMKDA 453

  Fly   452 EARWAAQESGIELDD---NYRDEDIF---ELQHHHLLRCLEKTTDREFVELEIPFNGQPKRPGSP 510
            .||      .||:.|   ....|.|.   ::|.:||.....|.|.|...|.....:.:.|..|||
  Rat   454 FAR------SIEMMDIVVEKNGESIAKKDKVQDNHLSPNKWKWTKRALSETSSSKSFETKEQGSP 512

  Fly   511 S---PMASPAH 518
            .   ..:||.|
  Rat   513 EKARSSSSPQH 523

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShalNP_001097646.1 BTB_POZ_Shal-like 6..144 CDD:349727 49/132 (37%)
Ion_trans 188..415 CDD:395416 96/233 (41%)
DUF3399 445..540 CDD:403174 25/84 (30%)
Kcnb1NP_037318.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 4/8 (50%)
BTB_POZ_KCNB2 15..141 CDD:349719 47/126 (37%)
Self-association. /evidence=ECO:0000269|PubMed:18463252, ECO:0000269|PubMed:19690160 59..75 1/15 (7%)
Ion_trans 188..424 CDD:395416 97/239 (41%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 377..382 3/4 (75%)
Self-association. /evidence=ECO:0000269|PubMed:18463252, ECO:0000269|PubMed:19690160 448..481 10/38 (26%)
Kv2channel 467..678 CDD:397541 16/57 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 476..524 14/48 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 540..569
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 610..658
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 770..802
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 818..857
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X19
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.810

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