DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and Kcna2

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_037102.1	Gene:	Kcna2 / 25468	RGDID:	2950	Length:	499	Species:	Rattus norvegicus

Alignment Length:	524	Identity:	179/524 - (34%)
Similarity:	283/524 - (54%)	Gaps:	101/524 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SVAAWLPFARAAAIGWVPIATHPLPPPPMPKDRRKTDD--------EKLLINVSGRRFETWRNTL 59
            :||...|...|||:            |..|:|   |.|        |:::||:||.||||...||
  Rat     2 TVATGDPVDEAAAL------------PGHPQD---TYDPEADHECCERVVINISGLRFETQLKTL 51

  Fly    60 EKYPDTLLGS-NEREFFYDEDCKEYFFDRDPDIFRHILNYYRT-GKLHYPKHECLTSYDEELAFF 122
            .::|:||||. .:|..::|....||||||:...|..||.||:: |:|..|.:..|..:.||:.|:
  Rat    52 AQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFY 116

  Fly   123 GIMPDVIGDCCYEDYRDRKRENAERLMDDKLSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVF 187
                 .:|:...|.:|:.:....|.  :..|.||         ..::::|..||.|.:|..|.:.
  Rat   117 -----ELGEEAMEMFREDEGYIKEE--ERPLPEN---------EFQRQVWLLFEYPESSGPARII 165

  Fly   188 YYVTGFFIAVSVMANVVETVP-----------------------CGHRPGRAGTLPCGERYKIVF 229
            ..|:...|.:|:::..:||:|                       .|::...:.|.|        |
  Rat   166 AIVSVMVILISIVSFCLETLPIFRDENEDMHGGGVTFHTYSNSTIGYQQSTSFTDP--------F 222

  Fly   230 FCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIMPYYIGLG--ITDNDD-------- 284
            |.::|.|::.|:.|:|:|.||.|.:..|..::|:|||:|||:||:|.||  :.:..:
  Rat   223 FIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQA 287

  Fly   285 VSGAFV-TLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATVMFYAEKN 348
            :|.|.: .:|:.|||||||.||||:||:|||.|||:...|||.|:|.|.:.:|:|::.:::||.:
  Rat   288 MSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAD 352

  Fly   349 VNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIY 413
            ...:.|.|||.|||:.:|:|||:|||||||.||.|||||.:|:::|||.||||||||||||:..|
  Rat   353 ERDSQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 417

  Fly   414 HQNQRADKRKAQRKARLARIRIA---------KASSGAAFVSKKKAAEARWAAQESGIELDDNYR 469
            |:     :.:.:.:|:..::...         |.|..|:.:||....|    .||.....::::|
  Rat   418 HR-----ETEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYME----IQEGVNNSNEDFR 473

  Fly   470 DEDI 473
            :|::
  Rat   474 EENL 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	48/147 (33%)
		Ion_trans	188..415	CDD:395416	107/260 (41%)
		DUF3399	445..540	CDD:403174	7/29 (24%)
Kcna2	NP_037102.1	Tetramerization domain. /evidence=ECO:0000305\|PubMed:11007484	1..125		48/142 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		11/38 (29%)
		BTB_POZ	33..159	CDD:365784	47/141 (33%)
		Ion_trans	162..420	CDD:395416	109/270 (40%)
		S4-S5 linker. /evidence=ECO:0000305\|PubMed:16002579	312..325		8/12 (67%)
		Selectivity filter. /evidence=ECO:0000305	374..379		3/4 (75%)
		PDZ-binding. /evidence=ECO:0000269\|PubMed:7477295	497..499
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810