DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and Kcnc2

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_631963.1	Gene:	Kcnc2 / 246153	RGDID:	628829	Length:	638	Species:	Rattus norvegicus

Alignment Length:	510	Identity:	163/510 - (31%)
Similarity:	255/510 - (50%)	Gaps:	120/510 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DDEKLLINVSGRRFETWRNTLEKYPDT---LLGSNEREFFYDEDC-------------------- 80
            ::|::::||.|.|.||:|:||:..|.|   ||.|:|.:    .||
  Rat     6 NNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPQ----GDCLTAAGDKLQPLPPPLSPPPR 66

  Fly    81 ---------------------------------KEYFFDRDPDIFRHILNYYRTGKLHYPKHECL 112
                                             :|:||||.|.:|.::||||||||||.|...|.
  Rat    67 PPPLSPVPSGCFEGGAGNCSSHGGNGSDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADVCG 131

  Fly   113 TSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMD--------------------------D 151
            ..::|||||:||....:..||:..||..:  :||..:|                          |
  Rat   132 PLFEEELAFWGIDETDVEPCCWMTYRQHR--DAEEALDIFETPDLIGGDPGDDEDLGGKRLGIED 194

  Fly   152 KLSENG-DQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVET------VPC 209
            .....| |....:...::.:||..||:|::|.:|....:.:.|||.||:....:||      |..
  Rat   195 AAGLGGPDGKSGRWRKLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKN 259

  Fly   210 GHRP---GRAGTLPCGERYKI----VFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDV 267
            ...|   |.:..|    :|:|    ....::..||:.||.|:|:|:..:|::.:|::::::|||.
  Rat   260 KTEPVINGTSAVL----QYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDF 320

  Fly   268 VAIMPYYIGLGITD-----NDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFL 327
            |||:|:|:.:|::.     ..||.|....:|..|:.||||.:||..|||:||:||::..:|...|
  Rat   321 VAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLL 385

  Fly   328 VFSLAMAIIIFATVMFYAEK---------NVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAG 383
            :..||:.::||||:::|||:         ....|.|.:||..||:.:|||||||||||.|:|.:|
  Rat   386 IIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSG 450

  Fly   384 KIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKA 438
            .:||.:|:|:|||.||:||||||:||...|.......|...:||..:....:|.:
  Rat   451 MLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPLASS 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	48/160 (30%)
		Ion_trans	188..415	CDD:395416	98/253 (39%)
		DUF3399	445..540	CDD:403174
Kcnc2	NP_631963.1	BTB	10..159	CDD:197585	47/152 (31%)
		BTB_2	10..151	CDD:280393	43/144 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..75		0/27 (0%)
		Ion_trans	277..484	CDD:278921	85/206 (41%)
		Ion_trans_2	<427..474	CDD:285168	30/46 (65%)
		Selectivity filter. /evidence=ECO:0000250	437..442		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	538..572
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810