DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and Kcna10

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_001074609.1	Gene:	Kcna10 / 242151	MGIID:	3037820	Length:	511	Species:	Mus musculus

Alignment Length:	424	Identity:	148/424 - (34%)
Similarity:	246/424 - (58%)	Gaps:	51/424 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 PPPPMPKDRRKTDDEKLLINVSGRRFETWRNTLEKYPDTLLGSNEREF-FYDEDCKEYFFDRDPD 90
            ||.|.|....: .:::::||::|.||||...||.::|:||||..|:.. |:|....||||||:..
Mouse    73 PPGPEPVVLNE-GNQRVIINIAGLRFETQLRTLNQFPETLLGDREKRMQFFDSMRNEYFFDRNRP 136

  Fly    91 IFRHILNYYRT-GKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDKLS 154
            .|..||.||:: ||:..|.:..:..:.:|::|:.:..:.:         |:.||:...:.|
Mouse   137 SFDGILYYYQSGGKIRRPANVPIDVFADEISFYELGSEAM---------DQFREDEGFIKD---- 188

  Fly   155 ENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVP----------- 208
               .:.|....:..::.|..||.|.:|::|.....|:...:.:|:....:||:|
Mouse   189 ---PETLLPTNDFHRQFWLLFEYPESSSAARGVAVVSVLVVVISITIFCLETLPEFREDRELKVV 250

  Fly   209 -----CGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVV 268
                 ..::.|.:.|:     :...||.:::.|::.||.|.:||....|.:..|.:::|:|||::
Mouse   251 RDPSINTNKTGLSQTM-----FTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFFKNIMNIIDII 310

  Fly   269 AIMPYYIGLGITD---------NDDVSGAFV-TLRVFRVFRIFKFSRHSQGLRILGYTLKSCASE 323
            :|:||:..| ||:         ..::|.|.: .:|:.|||||||.||||:||:|||.|||:...|
Mouse   311 SIIPYFATL-ITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRE 374

  Fly   324 LGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGG 388
            ||.|:|.|.:.:|:|::.:::||.:...::|:|||..||:.:|||||:|||||.|.|..|||||.
Mouse   375 LGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGT 439

  Fly   389 VCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKR 422
            :|:::|||.||||||||||||:..||:....:::
Mouse   440 LCAIAGVLTIALPVPVIVSNFNYFYHRETENEEK 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	39/118 (33%)
		Ion_trans	188..415	CDD:395416	99/252 (39%)
		DUF3399	445..540	CDD:403174
Kcna10	NP_001074609.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..44
		BTB_2	88..179	CDD:280393	34/99 (34%)
		BTB	88..171	CDD:197585	33/82 (40%)
		Ion_trans	267..467	CDD:278921	93/200 (47%)
		Ion_trans_2	382..458	CDD:285168	40/75 (53%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	421..426		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	489..511
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810