DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and Kcng2

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_001177302.1	Gene:	Kcng2 / 240444	MGIID:	3694646	Length:	480	Species:	Mus musculus

Alignment Length:	452	Identity:	143/452 - (31%)
Similarity:	224/452 - (49%)	Gaps:	61/452 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 HPLPPPPMP-------KDRRKTDDEKLLINVSGRRFETWRNTLEKYP-------------DTLLG 68
            ||..|...|       :..|......::|||.|.|.......|.:.|             |.||.
Mouse     7 HPEAPDAEPGSAGRRGRGGRGARARHVIINVGGCRVRLAWAALARCPLARLERLRACRGHDELLR 71

  Fly    69 SNEREFFYDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCC 133
            ..:.   ||....|:||||.|..||.|:...|.|||...:..|..::.:|||::||....:..||
Mouse    72 VCDD---YDVSRDEFFFDRSPCAFRAIVALLRAGKLRLLRGPCALAFRDELAYWGIDEARLERCC 133

  Fly   134 YEDYRDRKRENAE---------------RLMDDKLSENGDQNLQQLTNMRQKMWRAFENPHTSTS 183
            ....|.|:.|.||               |.:.....|.|.|.|:.:.          ||||:..:
Mouse   134 LRRLRRREEEAAEASAAQPARGPPTSPGRALGSGRLERGRQRLRDVV----------ENPHSGLA 188

  Fly   184 ALVFYYVTGFFIAVSVMANVVETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRL 248
            ..:|.||:..|:||:.:...:.|:|........|  .|..:.:.: |.|:|.||..|:.|:|||.
Mouse   189 GRLFAYVSVAFVAVTAVGLCLSTMPDVRAEEERG--ECSTKCRNL-FVLETVCVAWFSFEFLLRS 250

  Fly   249 FAAPDRCKFVRSVMSIIDVVAIMPYYIGL------GITDNDDVSGAFVTLRVFRVFR---IFKFS 304
            ..|..:|.|:|:.::|||::||:|:|:.|      |.|.:..:..|.:.||:.|..|   :.:.:
Mouse   251 LQAESKCAFLRTPLAIIDILAILPFYVSLLAGLAAGPTGSKMLERAGLVLRLLRALRVLYVMRLA 315

  Fly   305 RHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATVMFYAEKNVNG-TNFTSIPAAFWYTIVTM 368
            |||.|||.||.|::.||.|.|.|:..|.:|:.:||.::..||:.:.. .:|:|:||::|:.:::|
Mouse   316 RHSLGLRSLGLTVRRCAREFGLLLLFLCVAMALFAPLVHLAERELGAHRDFSSVPASYWWAVISM 380

  Fly   369 TTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARL 430
            ||:|||||||.::.|::|.....|||:|::|.||..|...|||.|.:.:...:|.|..:..|
Mouse   381 TTVGYGDMVPRSLPGQVVALSSILSGILLMAFPVTSIFHTFSRSYSELKEQQQRAASPEPAL 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	40/139 (29%)
		Ion_trans	188..415	CDD:395416	87/236 (37%)
		DUF3399	445..540	CDD:403174
Kcng2	NP_001177302.1	BTB_POZ	33..127	CDD:365784	31/96 (32%)
Kcng2	NP_001177302.1	Ion_trans	190..429	CDD:395416	88/241 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810