Protein Alignment Shal and Kcng3

DIOPT Version :10

• Sequence 1: NP_001097646.1
• Gene: Shal / 40129
• FlyBaseID: FBgn0005564
• Length: 571
• Species: Drosophila melanogaster
• Sequence 2: NP_705732.1
• Gene: Kcng3 / 225030
• MGIID: 2663923
• Length: 433
• Species: Mus musculus
• Alignment Length: 459
• Identity: 144/459 - (31%)
• Similarity: 228/459 - (49%)
• Gaps: 91/459 - (19%)

  Fly    43 LLINVSGRRFETWRNTLEKYP----DTLLG-SNEREFF-----YDEDCKEYFFDRDPDIFRHILN 97
            :::||.|.|:...|..|:.:|    ..|.| .:||:..     ||.:..||||||..:.|..||.
Mouse    11 VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGFILL 75

  Fly    98 YYR-TGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDKLSENGDQNL 161
            |.| .|||.:....|..|:..|:.::|:....:..||            :|.:||::|:....:.
Mouse    76 YVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCC------------QRRLDDRMSDTHTFHA 128

  Fly   162 QQLTNMRQ----------------KMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVP-- 208
            .......|                :|.|.||.|.:|.:|.:...|:..|:.||::.....|:|
Mouse   129 ADELGREQPRPAGPEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCASTLPDW 193

  Fly   209 ----CGHR-----------PGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFV 258
                ..:|           |||.   |.|        .::..|:..||||.::|...:.::|:||
Mouse   194 RAAVADNRSLDDRSRYSASPGRE---PSG--------IIEAICIGWFTAECIVRFIVSKNKCEFV 247

  Fly   259 RSVMSIIDVVAIMPYYIGLGIT----DNDDVSGAFVTLRVFRVFRIF---KFSRHSQGLRILGYT 316
            :..::|||::||.||||.:.:|    :|..:..|.|||||.|:.|||   |.:||..||:.||.|
Mouse   248 KRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVIKLARHFIGLQTLGLT 312

  Fly   317 LKSCASELGFLVFSLAMAIIIFATVMFYAEKNV----NGTNFTSIPAAFWYTIVTMTTLGYGDMV 377
            ||.|..|:..|:..:.:|:.||:.:....|..:    :..:|.|||||.|:.|::|||:|||||.
Mouse   313 LKRCYREMAMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFASIPAACWWVIISMTTVGYGDMY 377

  Fly   378 PETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSGA 442
            |.|:.|:|:||||.:||::::|||:..|..:|.:.||:.:       .|.||.:|      |..|
Mouse   378 PITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHELK-------FRSARYSR------SLSA 429

  Fly   443 AFVS 446
            .|::
Mouse   430 EFLN 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	33/111 (30%)
		Ion_trans	188..415	CDD:459842	91/254 (36%)
		DUF3399	471..535	CDD:463381
Kcng3	NP_705732.1	BTB_POZ_KCNG3	11..122	CDD:349729	36/122 (30%)
		Ion_trans	210..417	CDD:459842	85/217 (39%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	370..375		3/4 (75%)