DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shal and kvs-3

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_505407.2	Gene:	kvs-3 / 185719	WormBaseID:	WBGene00018402	Length:	451	Species:	Caenorhabditis elegans

Alignment Length:	428	Identity:	127/428 - (29%)
Similarity:	218/428 - (50%)	Gaps:	64/428 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VPIATHPLPPPPMPKDRRKTDDEKLLINVSG-----------RRFETWR-------NTLEKYPDT 65
            ||:...|: ..|:|........:.:.:||.|           ||..|.|       :.:|:..|.
Worm     5 VPLIESPV-AGPVPNGSVVRPPDIVFVNVGGRRARLNSDIIIRRLATSRLAVFCEKSHVERLTDC 68

  Fly    66 LLGSNEREFFYDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIG 130
                   :.|: |...||:|:|.|.||.:::::|.|||||.|...|......||.::.|....:.
Worm    69 -------DAFF-ESTSEYYFERSPIIFEYVIDFYVTGKLHRPMDICPIRLRYELDYWRIPTPFMS 125

  Fly   131 DCCYEDYRDR---KRENAERLMDDKLSEN-------GDQNLQQLTNMRQKMWRAFENPHTSTSAL 185
            .||..:..:.   |....:..:|..|..:       |.|.|        |::|..|||.:|:.|.
Worm   126 PCCILEENNNIAGKMSTEKAFVDSSLPSSCFDKVVLGPQRL--------KLYRLMENPRSSSGAK 182

  Fly   186 VFYYVTGFFIAVSVMANVVETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFA 250
            :|...:..|:.:|::..::.::|......:       |.:.::.: |:..|::.||.|||.||..
Worm   183 IFSVGSALFVLLSLLGLILSSMPELQDENK-------EPHYLLHW-LELLCMVYFTFEYLARLLV 239

  Fly   251 APDRCKFVRSVMSIIDVVAIMPYYIGLGITDND-----DVSGAFVTLRVF---RVFRIFKFSRHS 307
            .|.:.:|:||.:::||::.::|:.|.   ..|:     :..||.:.:||.   ||.||||.:|:|
Worm   240 NPKKAEFIRSPLNVIDLLTVLPFMIE---AFNELQWMKEFRGAMLVVRVMRLARVARIFKLARYS 301

  Fly   308 QGLRILGYTLKSCASELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLG 372
            .|||..|.|:|..|:||..|...|...|::|:|.:::.|::...:.|.|||||.|:.::||||:|
Worm   302 TGLRAFGETMKKSAAELSMLGMFLVTGIMLFSTAIYFFERDEPNSKFYSIPAACWWCVITMTTVG 366

  Fly   373 YGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFS 410
            |||:||.|..||:|..:.|:.|::|:|.|:.:|:..|:
Worm   367 YGDLVPITAGGKVVAALASVCGIIVLAFPISMIIDKFA 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	37/145 (26%)
		Ion_trans	188..415	CDD:395416	77/231 (33%)
		DUF3399	445..540	CDD:403174
kvs-3	NP_505407.2	BTB	26..133	CDD:197585	31/114 (27%)
		BTB_2	28..127	CDD:280393	29/106 (27%)
		Ion_trans	206..407	CDD:278921	74/210 (35%)
		Ion_trans_2	324..405	CDD:285168	33/81 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810