DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and kvs-1

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_001360715.1	Gene:	kvs-1 / 183753	WormBaseID:	WBGene00002242	Length:	499	Species:	Caenorhabditis elegans

Alignment Length:	445	Identity:	137/445 - (30%)
Similarity:	222/445 - (49%)	Gaps:	90/445 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 DRRKTD------DEKLLINVSGRRFET------WRNTLEKYPDTLLGSNEREFFYDEDC------ 80
            |..|.|      |..:.:||.|..|..      .|:..||.......::|:..   :.|
Worm    58 DEVKPDLVSGAGDTVIKLNVGGTSFRIRISSIFARSADEKLSAFAQLNHEQRL---QACDAFLMP 119

  Fly    81 -KEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDY------- 137
             :||:.:|...:|..|..||.:|:||.|...|.|.:..|||::.|...::.:||:..|
Worm   120 QEEYYLERSAVLFDSIFKYYISGQLHRPLDVCPTEFATELAYWKINDGLMSNCCWRGYNMSPSLE 184

  Fly   138 -----RDRKRENAERLMDDKLSE--NGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFI 195
                 :::|.|..:|.|..::.:  .||.:|                   .::...|..:|  |:
Worm   185 ELVAPKEKKIELHDRSMRSRIHQFCEGDGSL-------------------FSTLFTFGSIT--FV 228

  Fly   196 AVSVMANVVET-----VPCGHRPGRA------------GTLPCGERYKI------VFFCLDTACV 237
            .:||:..|:.:     ||...:.|::            ||....|...|      :|..::|.|:
Worm   229 LISVIGLVLGSIHEFQVPIYKKGGKSERISNWSIADQNGTDSSVENENIIWEPHPIFGYVETVCI 293

  Fly   238 MIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIMPYYIGLG-------ITDNDDVSGAFV---TL 292
            :.||.|:::||...|:|.:|:..:|:|:|::||:|:|:.||       :....|:.||.:   .|
Worm   294 IWFTVEFIVRLAVTPNRFQFLVGIMNIVDMIAIIPFYLELGLALFGIDVASLSDIKGALLVVRVL 358

  Fly   293 RVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSI 357
            ||.||.||.|..|:|.|:|....||||.|.:||.:...|:..::.|:|::::.||:...|.||||
Worm   359 RVLRVVRILKLGRYSSGMRTFALTLKSSARQLGMMGMVLSTGVVFFSTLLYFVEKDEKDTPFTSI 423

  Fly   358 PAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRI 412
            |||||:.||||||:||||.||.|:.||::.....:|||||:|||:.:||.||.::
Worm   424 PAAFWWAIVTMTTVGYGDYVPVTVPGKLIASGAIISGVLVLALPITIIVDNFMKV 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	34/140 (24%)
		Ion_trans	188..415	CDD:395416	96/258 (37%)
		DUF3399	445..540	CDD:403174
kvs-1	NP_001360715.1	BTB_POZ_Kv	73..163	CDD:349626	25/92 (27%)
kvs-1	NP_001360715.1	Ion_trans	276..475	CDD:366146	83/198 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910