DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shal and egl-36

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_509795.1	Gene:	egl-36 / 181269	WormBaseID:	WBGene00001202	Length:	558	Species:	Caenorhabditis elegans

Alignment Length:	517	Identity:	169/517 - (32%)
Similarity:	264/517 - (51%)	Gaps:	78/517 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 DRRKTDDEKLLINVSGRRFETWRNTLEKYPDTLLG------SNEREFFYDEDCKEYFFDRDPDIF 92
            |:..:.||::::||.|.|.||::.||:|.|.|.|.      :|     :|....||||||.|.:|
Worm    30 DKGISMDERIVLNVGGVRHETYQATLKKIPATRLSRLTPSLAN-----FDPLLNEYFFDRHPAVF 89

  Fly    93 RHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDKL--SE 155
            ..|||||||||||||...|...::|||.::|:.......||:......|.......:.|::  ..
Worm    90 AMILNYYRTGKLHYPTDVCGPLFEEELQYWGLDASDTEPCCWMQLLHAKDTQETLAVLDRMDADH 154

  Fly   156 NGDQNLQQLTNMRQ--------------------KMWRAFENPHTSTSALVFYYVTGFFIAVSVM 200
            ..|..|::...|::                    :||..|:.|::|.:|.:...::..||.:|:.
Worm   155 EDDPQLREQDTMKKFGWEEDYFQGKRTRWMKLKPQMWSLFDEPYSSQAAKLIAGISVLFIFISIF 219

  Fly   201 ANVVETVPCGHRP---GRAGTLPCG------ERYKI----VFFCLDTACVMIFTAEYLLRLFAAP 252
            :..::|......|   |:..|:|.|      ||...    :|..::..|.:.||.|.::|....|
Worm   220 SFCLKTHQSFRLPVLIGQNITMPGGVVQPSIERVSTEPLPIFGQIEMLCNIWFTLELIIRFVFCP 284

  Fly   253 DRCKFVRSVMSIIDVVAIMPYYIGLGITD--NDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGY 315
            .:.:|.:|.:::||:||.:.:|....:..  .|:.......|.:.|:||:||.::|.|||:||.:
Worm   285 SKIRFFKSPLNMIDLVATLSFYADAMMVRVVEDEPKDVVEFLSMIRIFRLFKLTQHHQGLQILIH 349

  Fly   316 TLKSCASELGFLVFSLAMAIIIFATVMFYAEK-NVNGTN-FTSIPAAFWYTIVTMTTLGYGDMVP 378
            |.::.|.||..|||.|.:.|:|||.:::|||| ..|..| |.|||...|:.|.||||:|||||.|
Worm   350 TFRASAKELILLVFFLILGIVIFAALVYYAEKMEANPNNQFQSIPLGLWWAICTMTTVGYGDMTP 414

  Fly   379 ETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADK--RKAQRKARLARIRIAKASSG 441
            .|..|::||.:|::.|||.||||||||||||:..|..||..||  ::.:|...:.:||:.
Worm   415 HTSFGRLVGSLCAVMGVLTIALPVPVIVSNFAMFYSHNQARDKLPKRRRRVLPVEQIRLQ----- 474

  Fly   442 AAFVSKKKAAEARWAAQESG-------------IELDDNYRDEDIFELQHHHLLRCLEKTTD 490
                :::.||....:|.:.|             |.:|.|..||:    .|:|..|...:.:|
Worm   475 ----ARRHAAVLEPSASQGGLGGGQAIRRRNMPILIDQNCCDEE----NHNHKHREKSENSD 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	46/115 (40%)
		Ion_trans	188..415	CDD:395416	93/243 (38%)
		DUF3399	445..540	CDD:403174	13/59 (22%)
egl-36	NP_509795.1	BTB	39..132	CDD:197585	42/97 (43%)
		BTB_2	39..129	CDD:280393	40/94 (43%)
		Ion_trans	254..451	CDD:278921	82/196 (42%)
		Ion_trans_2	369..451	CDD:285168	47/81 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810