DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and KCNG3

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_579875.1	Gene:	KCNG3 / 170850	HGNCID:	18306	Length:	436	Species:	Homo sapiens

Alignment Length:	448	Identity:	142/448 - (31%)
Similarity:	224/448 - (50%)	Gaps:	88/448 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LLINVSGRRFETWRNTLEKYP----DTLLG-SNEREFF-----YDEDCKEYFFDRDPDIFRHILN 97
            :::||.|.|:...|..|:.:|    ..|.| .:||:..     ||.:..||||||..:.|..||.
Human    11 VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGFILL 75

  Fly    98 YYR-TGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDKLSEN----- 156
            |.| .|||.:....|..|:..|:.::|:....:..||            :|.:||::|:.
Human    76 YVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCC------------QRRLDDRMSDTYTFYS 128

  Fly   157 --------------GDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETV 207
                          |...........::|.|.||.|.:|.:|.:...|:..|:.||::.....|:
Human   129 ADEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCASTL 193

  Fly   208 P------CGHR-----------PGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRC 255
            |      ..:|           |||.   |.|        .::..|:..||||.::|...:.::|
Human   194 PDWRNAAADNRSLDDRSRYSAGPGRE---PSG--------IIEAICIGWFTAECIVRFIVSKNKC 247

  Fly   256 KFVRSVMSIIDVVAIMPYYIGLGIT----DNDDVSGAFVTLRVFRVFRIF---KFSRHSQGLRIL 313
            :||:..::|||::||.||||.:.:|    :|..:..|.|||||.|:.|||   |.:||..||:.|
Human   248 EFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVIKLARHFIGLQTL 312

  Fly   314 GYTLKSCASELGFLVFSLAMAIIIFATVMFYAEKNV----NGTNFTSIPAAFWYTIVTMTTLGYG 374
            |.|||.|..|:..|:..:.:|:.||:.:....|..:    :..:|||||||.|:.|::|||:|||
Human   313 GLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSIPAACWWVIISMTTVGYG 377

  Fly   375 DMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLAR 432
            ||.|.|:.|:|:||||.:||::::|||:..|..:|.:.||:.:       .|.||.:|
Human   378 DMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHELK-------FRSARYSR 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	33/111 (30%)
		Ion_trans	188..415	CDD:395416	92/254 (36%)
		DUF3399	445..540	CDD:403174
KCNG3	NP_579875.1	BTB_POZ_KCNG3	11..122	CDD:349729	36/122 (30%)
		Ion_trans	219..420	CDD:395416	83/211 (39%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	373..378		3/4 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810