DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and Kcns2

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_001258633.1	Gene:	Kcns2 / 16539	MGIID:	1197011	Length:	477	Species:	Mus musculus

Alignment Length:	415	Identity:	136/415 - (32%)
Similarity:	223/415 - (53%)	Gaps:	38/415 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DDEKLLINVSGRRFETWRNTLEKYPDTLLG----SNEREFF------YDEDCKEYFFDRDPDIFR 93
            :|.::.|||.|.:.....:||.::|:|.||    .:.||..      ||:..:|::|||:|::|.
Mouse    15 EDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFP 79

  Fly    94 HILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDKLSENG- 157
            ::|::|.|||||.....|:.|:.:|:.::||....|..||...|..||.|..:...|::..:..
Mouse    80 YVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQSDQEST 144

  Fly   158 ----DQNL-----------QQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETV 207
                |:.|           |.|.|.|:::|.|.:||..|..:.||..::...:..|::...:.::
Mouse   145 TSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSVLSILVVLGSIITMCLNSL 209

  Fly   208 PCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIMP 272
            |....|...|......|::||    :...:..||.|.:.|...|||..||.::.:::||:::|:|
Mouse   210 PDFQIPDSQGNPGEDPRFEIV----EHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVP 270

  Fly   273 YYIGLGITDNDDVSGAFV-------TLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLVFS 330
            :||.|.:....:.|....       .||:.|:|||.|.:|||.|||.||.|||....|:|.|:..
Mouse   271 FYITLVVNLVVESSPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLY 335

  Fly   331 LAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGV 395
            |::.|.||:.|.:..||..| ....:|||.:|:..|:|||:||||:||.|.|||:....|.|:|:
Mouse   336 LSVGISIFSVVAYTIEKEEN-EGLATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGI 399

  Fly   396 LVIALPVPVIVSNFSRIYHQNQRAD 420
            ||:.||:.:|.:.||..|.:.::.:
Mouse   400 LVVVLPITLIFNKFSHFYRRQKQLE 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	39/114 (34%)
		Ion_trans	188..415	CDD:395416	82/233 (35%)
		DUF3399	445..540	CDD:403174
Kcns2	NP_001258633.1	BTB_2	19..118	CDD:308049	33/98 (34%)
		Ion_trans	186..421	CDD:306908	84/239 (35%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	374..379		3/4 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810