DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shal and Kcns1

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_032461.2	Gene:	Kcns1 / 16538	MGIID:	1197019	Length:	497	Species:	Mus musculus

Alignment Length:	467	Identity:	140/467 - (29%)
Similarity:	224/467 - (47%)	Gaps:	65/467 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 IATHPLPPPPMPKDRRKTDDEKLLINVSGRRFETWRNTLEKYPDTLLG-----SNEREF-----F 75
            ::..|.|...:|...|   ||.|.:||.|.|.......|.::|.|.||     ::|.:.     .
Mouse     2 VSEFPGPGSRVPWRPR---DEALRVNVGGVRRLLSARALARFPGTRLGRLQAAASEEQARRLCDD 63

  Fly    76 YDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDR 140
            ||....|::|||.|..|..:|::||||.||.....|:.::.:|..::|:..:.:..||...|.:|
Mouse    64 YDAAAHEFYFDRHPGFFLGLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALATCCRARYLER 128

  Fly   141 K---------RENAERLMD---DKLS----ENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYY 189
            :         ..:|...:|   |::|    |.......:...:|:::|...|||..|..:.:|..
Mouse   129 RVARPRAWDEDSDAPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSC 193

  Fly   190 VTGFFIAVSVMANVVETVP---CGHRPGRAGTLPCGE-----RYKIVFFCLDTACVMIFTAEYLL 246
            |:...:..|:.|..:.::|   ..........:..|.     |...|...|:..|:..|:.|...
Mouse   194 VSIGVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSAEEVRDDPVLRRLEYFCIAWFSFEVSS 258

  Fly   247 RLFAAPDRCKFVRSVMSIIDVVAIMPYYI----GLGITDNDDVSG--------AFVTLRVFRVFR 299
            ||..||....|....:::||:|:::|:|:    |..:.|....||        .....|:.|:||
Mouse   259 RLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGAALGDQRGASGEELGDLGKVVQVFRLMRIFR 323

  Fly   300 IFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYT 364
            :.|.:|||.|||.||.|||....|:|.|:..||:.:.:|:.|.:.||:...|  |.:|||.:|:.
Mouse   324 VLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEEENEG--FHTIPACWWWG 386

  Fly   365 IVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKAR 429
            .|:|||:||||:||||:.||:....|.|.|:||:|||:.:|.:.||..|.          ::||.
Mouse   387 TVSMTTVGYGDVVPETVGGKLAASGCILGGILVVALPITIIFNKFSHFYR----------RQKAL 441

  Fly   430 LARIRIAKASSG 441
            .|.:|    |||
Mouse   442 EAAVR----SSG 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	39/141 (28%)
		Ion_trans	188..415	CDD:395416	82/246 (33%)
		DUF3399	445..540	CDD:403174
Kcns1	NP_032461.2	BTB_POZ	21..126	CDD:365784	31/104 (30%)
		Ion_trans	188..439	CDD:395416	83/262 (32%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	392..397		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810