DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and Kcnq2

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	XP_017171224.1	Gene:	Kcnq2 / 16536	MGIID:	1309503	Length:	937	Species:	Mus musculus

Alignment Length:	456	Identity:	95/456 - (20%)
Similarity:	171/456 - (37%)	Gaps:	126/456 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 MWRAFENP-------HTSTSALVFYYVTGFFIAVSVMANVVETVPCGHRPGRAGTLPCGERYKIV 228
            ::...|.|       |.....|||     ..:.:||.:.:.|     :.....|.|
Mouse    81 LYNVLERPRGWAFIYHAYVFLLVF-----SCLVLSVFSTIKE-----YEKSSEGAL--------- 126

  Fly   229 FFCLDTACVMIFTAEYLLRLFAA---------PDRCKFVRSVMSIIDVVAIMP--YYIGLGITDN 282
             :.|:...:::|..||.:|::||         ..|.||.|....:||::.::.  ..:..|...|
Mouse   127 -YILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGN 190

  Fly   283 DDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASEL------GFLVFSLAMAIIIFATV 341
            ...:.|..:||..::.|:.:..|.....::||..:.:.:.||      |||      .:|:.:.:
Mouse   191 VFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFL------CLILASFL 249

  Fly   342 MFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIV 406
            ::.|||..| .:|.:...|.|:.::|:||:||||..|:|..|:::....:|.||...|||..::.
Mouse   250 VYLAEKGEN-DHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILG 313

  Fly   407 SNFS---RIYHQNQRADKRKAQRKARLARIRIAKASSGAAFVSKKKAAEARWAAQESGIELDDNY 468
            |.|:   :..|:.:..:||:               :..|..:      ::.|....:.:...|.:
Mouse   314 SGFALKVQEQHRQKHFEKRR---------------NPAAGLI------QSAWRFYATNLSRTDLH 357

  Fly   469 RDEDIFE-----------------------LQHHHLLRCLEKTTDREFVELEIPFNGQPKRPGSP 510
            .....:|                       |....|||.|:..:.       :.|..:|:...||
Mouse   358 STWQYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSG-------LTFRKEPQPEPSP 415

  Fly   511 SPMASPAHSTNSAAGLLQSCCGRCCSQRYQ-------------ACGKYMPAASNAQNSQN-NQPM 561
            |       ......|.|..||....||:..             |.||..|.|...:.|.: :|.:
Mouse   416 S-------KGRPCRGCLCGCCPGHSSQKVSLKDRVFSSPRGMAAKGKGSPQAQTVRRSPSADQSL 473

  Fly   562 D 562
            |
Mouse   474 D 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727
		Ion_trans	188..415	CDD:395416	58/246 (24%)
		DUF3399	445..540	CDD:403174	19/117 (16%)
Kcnq2	XP_017171224.1	Ion_trans	92..324	CDD:366146	62/258 (24%)
		KCNQ_channel	466..719	CDD:367540	3/9 (33%)
		KCNQ2_u3	734..821	CDD:374697
		KCNQC3-Ank-G_bd	840..933	CDD:371819
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810