DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shal and Kcna5

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_666095.1	Gene:	Kcna5 / 16493	MGIID:	96662	Length:	602	Species:	Mus musculus

Alignment Length:	568	Identity:	193/568 - (33%)
Similarity:	295/568 - (51%)	Gaps:	120/568 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ATH--------PLPPPP--MPKDRRKT--DDE-------------------------KLLINVSG 49
            |||        ||||.|  :|:.||.:  |:|                         ::|||:||
Mouse    55 ATHEDAGQGGRPLPPMPQELPQPRRPSAEDEEGEGDPGLGTVEEDQAPQDSGSLHHQRVLINISG 119

  Fly    50 RRFETWRNTLEKYPDTLLGSN-EREFFYDEDCKEYFFDRDPDIFRHILNYYRT-GKLHYPKHECL 112
            .||||...||.::|:||||.. :|..::|....||||||:...|..||.||:: |:|..|.:..|
Mouse   120 LRFETQLGTLAQFPNTLLGDPVKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSL 184

  Fly   113 TSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDKLSENGDQNLQQLTNMRQKMWRAFEN 177
            ..:.:|:.|:     .:||...|.:|:          |:...:..::.|.: ...::::|..||.
Mouse   185 DVFADEIRFY-----QLGDEAMERFRE----------DEGFIKEEEKPLPR-NEFQRQVWLIFEY 233

  Fly   178 PHTSTSALVFYYVTGFFIAVSVMANVVETVP--------CGHRP--------------GRAGTLP 220
            |.:|.||.....|:...|.:|::...:||:|        ..|.|              ..:|.|.
Mouse   234 PESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPVPPQPPAPAPGANGSGSGVLS 298

  Fly   221 CGERYKIV--------FFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIMPYYIGL 277
            .|.....:        ||.::|.||:.||.|.|:|.||.|.:.:|.|::|:|||:|||.||:|.|
Mouse   299 SGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAEFSRNIMNIIDIVAIFPYFITL 363

  Fly   278 GIT----------DNDDVSGAFVTLRVF---RVFRIFKFSRHSQGLRILGYTLKSCASELGFLVF 329
            |..          .|...:.:...|||.   |||||||.||||:||:|||.||::...|||.|:|
Mouse   364 GTELAEQQPGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIF 428

  Fly   330 SLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSG 394
            .|.:.:|:|::.:::||.:..|::|:|||.|||:.:|||||:|||||.|.|:.|||||.:|:::|
Mouse   429 FLFIGVILFSSAVYFAEADNQGSHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAG 493

  Fly   395 VLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSGAAFVSKKKAAEARWAAQE 459
            ||.||||||||||||:..||:....:::.|.::.:    .|.:..||.....::|.:.::.:..:
Mouse   494 VLTIALPVPVIVSNFNYFYHRETDHEEQAALKEEQ----GIQRRESGLDTGGQRKVSCSKASFCK 554

  Fly   460 SG--IELDDNYRDEDIFELQHHHL-------LR------CLEKTTDRE 492
            :|  :|..|:.| .....|:..||       ||      ||:  |.||
Mouse   555 TGGPLESTDSIR-RGSCPLEKCHLKAKSNVDLRRSLYALCLD--TSRE 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	52/160 (33%)
		Ion_trans	188..415	CDD:395416	112/269 (42%)
		DUF3399	445..540	CDD:403174	15/63 (24%)
Kcna5	NP_666095.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..107		13/51 (25%)
		BTB	113..207	CDD:197585	39/108 (36%)
		BTB_2	113..204	CDD:280393	38/95 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	274..297		3/22 (14%)
		Ion_trans	305..515	CDD:278921	102/209 (49%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	407..420		7/12 (58%)
		Ion_trans_2	429..506	CDD:285168	42/76 (55%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	469..474		3/4 (75%)
		PDZ-binding	600..602		193/568 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810