DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and Kcna4

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_067250.2	Gene:	Kcna4 / 16492	MGIID:	96661	Length:	654	Species:	Mus musculus

Alignment Length:	469	Identity:	165/469 - (35%)
Similarity:	263/469 - (56%)	Gaps:	72/469 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EKLLINVSGRRFETWRNTLEKYPDTLLGSNE-REFFYDEDCKEYFFDRDPDIFRHILNYYRT-GK 103
            |:::|||||.||||...||.::|:||||..| |..::|....||||||:...|..||.||:: |:
Mouse   177 ERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGR 241

  Fly   104 LHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDK-LSENGDQNLQQLTNM 167
            |..|.:.....:.||:.|:.:..:.:       .:.|:.|...|..:|: |.||         ..
Mouse   242 LKRPVNVPFDIFTEEVKFYQLGEEAL-------LKFREDEGFVREEEDRALPEN---------EF 290

  Fly   168 RQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVPCGHRPGR--AGTLPCGERYKIV-- 228
            ::::|..||.|.:|:.|.....|:...|.:|::...:||:| ..|..|  ...|..|...:::
Mouse   291 KKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLP-EFRDDRDLIMALSAGGHSRLLND 354

  Fly   229 -----------------FFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIMPYYIG 276
                             ||.::|.|::.|:.|:::|.||.|.:..|.:::|:|||:|:|:||:|.
Mouse   355 TSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFIT 419

  Fly   277 LGITDNDDVSG----------AFVTLRVF---RVFRIFKFSRHSQGLRILGYTLKSCASELGFLV 328
            || ||.....|          :|..||:.   |||||||.||||:||:|||:||::...|||.|:
Mouse   420 LG-TDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLI 483

  Fly   329 FSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLS 393
            |.|.:.:|:|::.:::||.:...|:|.|||.|||:.:|||||:|||||.|.|:.|||||.:|:::
Mouse   484 FFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIA 548

  Fly   394 GVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIA------------KASSGAAFVS 446
            |||.||||||||||||:..||:     :.:.:.:.:|.:..::            ::|:.::...
Mouse   549 GVLTIALPVPVIVSNFNYFYHR-----ETENEEQTQLTQNAVSCPYLPSNLLKKFRSSTSSSLGD 608

  Fly   447 KKKAAEARWAAQES 460
            |.:..|.....:||
Mouse   609 KSEYLEMEEGVKES 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	38/104 (37%)
		Ion_trans	188..415	CDD:395416	108/260 (42%)
		DUF3399	445..540	CDD:403174	4/16 (25%)
Kcna4	NP_067250.2	K_channel_TID	1..>37	CDD:369607
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..145
		BTB_POZ	177..304	CDD:365784	48/142 (34%)
		Ion_trans	307..571	CDD:366146	110/270 (41%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	463..476		7/12 (58%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	525..530		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	630..654
		PDZ-binding. /evidence=ECO:0000250	652..654
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810