DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and Kcna3

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_032444.2	Gene:	Kcna3 / 16491	MGIID:	96660	Length:	528	Species:	Mus musculus

Alignment Length:	455	Identity:	163/455 - (35%)
Similarity:	248/455 - (54%)	Gaps:	63/455 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PLPPPPMPKDRRKTDDEKLLINVSGRRFETWRNTLEKYPDTLLGSNEREF-FYDEDCKEYFFDRD 88
            ||||.......:....|:::||:||.||||...||.::|:||||..:|.. ::|....||||||:
Mouse    41 PLPPALPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRN 105

  Fly    89 PDIFRHILNYYRT-GKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDK 152
            ...|..||.||:: |::..|.:..:..:.||:.|:     .:|:...|.:|:          |:.
Mouse   106 RPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFY-----QLGEEAMEKFRE----------DEG 155

  Fly   153 LSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVP-------CG 210
            .....::.|.:....|| :|..||.|.:|..|.....|:...|.:|::...:||:|       ..
Mouse   156 FLREEERPLPRRDFQRQ-VWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYP 219

  Fly   211 HRPGR----------AGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSII 265
            ..|.:          :|.......:...||.::|.|::.|:.|.|:|.||.|.:..|.|::|::|
Mouse   220 ASPSQDVFEAANNSTSGAPSGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLI 284

  Fly   266 DVVAIMPYYIGLGI-----TDNDDVSGAFVTLRVF---RVFRIFKFSRHSQGLRILGYTLKSCAS 322
            |:|||:||:|.||.     ..|...:.:...|||.   |||||||.||||:||:|||.|||:...
Mouse   285 DIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMR 349

  Fly   323 ELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVG 387
            |||.|:|.|.:.:|:|::.:::||.:...:.|.|||.|||:.:|||||:|||||.|.||.|||||
Mouse   350 ELGLLIFFLFIGVILFSSAVYFAEADDPSSGFNSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVG 414

  Fly   388 GVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADK--------------------RKAQRKARLAR 432
            .:|:::|||.||||||||||||:..||:....::                    |||:..:.|::
Mouse   415 SLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYMHVGSCQHLSSSAEELRKARSNSTLSK 479

Fly 433 432
Mouse 480 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	41/120 (34%)
		Ion_trans	188..415	CDD:395416	107/251 (43%)
		DUF3399	445..540	CDD:403174
Kcna3	NP_032444.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		BTB	59..153	CDD:197585	36/108 (33%)
		BTB_2	59..150	CDD:280393	35/95 (37%)
		Ion_trans	243..443	CDD:278921	100/199 (50%)
		Ion_trans_2	357..434	CDD:285168	42/76 (55%)
		Selectivity filter. /evidence=ECO:0000250	397..402		3/4 (75%)
		PDZ-binding. /evidence=ECO:0000250	526..528
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810