DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shal and Kcna1

DIOPT Version :9

Sequence 1:NP_001097646.1 Gene:Shal / 40129 FlyBaseID:FBgn0005564 Length:571 Species:Drosophila melanogaster
Sequence 2:NP_034725.3 Gene:Kcna1 / 16485 MGIID:96654 Length:495 Species:Mus musculus


Alignment Length:488 Identity:174/488 - (35%)
Similarity:271/488 - (55%) Gaps:73/488 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 PPMPKD-----RRKTDD----EKLLINVSGRRFETWRNTLEKYPDTLLGS-NEREFFYDEDCKEY 83
            |..|:|     :...||    |:::||:||.||||...||.::|:||||: .:|..::|....||
Mouse    16 PGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEY 80

  Fly    84 FFDRDPDIFRHILNYYRT-GKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAER 147
            ||||:...|..||.||:: |:|..|.:..|..:.||:.|:     .:|:...|.:|:        
Mouse    81 FFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFY-----ELGEEAMEKFRE-------- 132

  Fly   148 LMDDKLSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVP---- 208
              |:...:..::.|.:....|| :|..||.|.:|..|.|...|:...|.:|::...:||:|    
Mouse   133 --DEGFIKEEERPLPEKEYQRQ-VWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKD 194

  Fly   209 ----CG--HRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDV 267
                .|  ||......:.....:...||.::|.|::.|:.|.::|.||.|.:..|.:::|:.||:
Mouse   195 DKDFTGTIHRIDNTTVIYTSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDI 259

  Fly   268 VAIMPYYIGLG--ITDND-DVSGAFVT-------LRVFRVFRIFKFSRHSQGLRILGYTLKSCAS 322
            |||:||:|.||  |.:.: :..|...|       :|:.|||||||.||||:||:|||.|||:...
Mouse   260 VAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMR 324

  Fly   323 ELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVG 387
            |||.|:|.|.:.:|:|::.:::||.....::|:|||.|||:.:|:|||:|||||.|.||.|||||
Mouse   325 ELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVG 389

  Fly   388 GVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASS-------GAAFV 445
            .:|:::|||.||||||||||||:..||:     :.:.:.:|:|..:.....:|       .::.:
Mouse   390 SLCAIAGVLTIALPVPVIVSNFNYFYHR-----ETEGEEQAQLLHVSSPNLASDSDLSRRSSSTI 449

  Fly   446 SKKKAAEARWAAQESGIELDDN-----YRDEDI 473
            ||.:..|         ||.|.|     ||..:|
Mouse   450 SKSEYME---------IEEDMNNSIAHYRQANI 473

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShalNP_001097646.1 BTB_POZ_Shal-like 6..144 CDD:349727 44/125 (35%)
Ion_trans 188..415 CDD:395416 105/246 (43%)
DUF3399 445..540 CDD:403174 10/34 (29%)
Kcna1NP_034725.3 Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P10499 1..128 42/116 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30 3/13 (23%)
BTB_POZ 37..163 CDD:365784 47/141 (33%)
Ion_trans 166..418 CDD:366146 108/256 (42%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 310..323 8/12 (67%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 372..377 3/4 (75%)
PDZ-binding. /evidence=ECO:0000250 493..495
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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