DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shal and Kcns1

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_446406.1	Gene:	Kcns1 / 117023	RGDID:	621524	Length:	497	Species:	Rattus norvegicus

Alignment Length:	494	Identity:	146/494 - (29%)
Similarity:	234/494 - (47%)	Gaps:	62/494 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 IATHPLPPPPMPKDRRKTDDEKLLINVSGRRFETWRNTLEKYPDTLLG------SNERE----FF 75
            ::..|.|...:|...|   ||.|.:||.|.|.......|.::|.|.||      |.|:.    ..
  Rat     2 VSEFPGPGSRVPWRPR---DEALRVNVGGVRRLLSARALARFPGTRLGRLQAAVSEEQARRLCDD 63

  Fly    76 YDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDR 140
            ||...:|::|||.|..|..:|::||||.||.....|:.::.:|..::|:..:.:..||...|.:|
  Rat    64 YDAAAREFYFDRHPGFFLGLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALATCCRARYLER 128

  Fly   141 KRENAERLMD-------------DKLS----ENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFY 188
             |....|..|             |::|    |.......:...:|:::|...|||..|..:.:|.
  Rat   129 -RVTRPRAWDEDSDAPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFS 192

  Fly   189 YVTGFFIAVSVMANVVETVP---CGHRPGRAGTLPCGE-----RYKIVFFCLDTACVMIFTAEYL 245
            .|:...:..|:.|..:.::|   ..........:..|.     |...|...|:..|:..|:.|..
  Rat   193 CVSIGVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSAEDVRDDPVLRRLEYFCIAWFSFEVS 257

  Fly   246 LRLFAAPDRCKFVRSVMSIIDVVAIMPYYI----GLGITDNDDVSG--------AFVTLRVFRVF 298
            .||..||....|....:::||:|:::|:|:    |..:.|....||        .....|:.|:|
  Rat   258 SRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGAALGDRRGASGEELGDLGKVVQVFRLMRIF 322

  Fly   299 RIFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATVMFYA-EKNVNGTNFTSIPAAFW 362
            |:.|.:|||.|||.||.|||....|:|.|:..||:.:.:|:.|.:.| ||||   .|.:|||.:|
  Rat   323 RVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEEKNV---GFDTIPACWW 384

  Fly   363 YTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQN---QRADKRKA 424
            :..|:|||:||||:||||:|||:....|.|.|:||:|||:.:|.:.||..|.:.   :.|.:...
  Rat   385 WGTVSMTTVGYGDVVPETVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRSSG 449

  Fly   425 QRKARLARIRIAKASSGAAFVSKKKAAEARWAAQESGIE 463
            ||:..    .:..:..|.:.||.:.:.|.....:.:.:|
  Rat   450 QREFE----DLLSSVDGVSDVSLETSRETSQEGRSTDLE 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	41/132 (31%)
		Ion_trans	188..415	CDD:395416	85/247 (34%)
		DUF3399	445..540	CDD:403174	4/19 (21%)
Kcns1	NP_446406.1	BTB_2	21..120	CDD:280393	30/98 (31%)
		BTB	23..125	CDD:197585	31/101 (31%)
		Ion_trans	238..439	CDD:278921	79/203 (39%)
		Ion_trans_2	355..433	CDD:285168	39/80 (49%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	392..397		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..497		4/21 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810