DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and Kcnq3

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_690887.2	Gene:	Kcnq3 / 110862	MGIID:	1336181	Length:	873	Species:	Mus musculus

Alignment Length:	328	Identity:	79/328 - (24%)
Similarity:	141/328 - (42%)	Gaps:	75/328 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 RENAER--------LMDDKLSENGDQNLQQLTNMRQKMWRAFENP-------HTSTSALVFYYVT 191
            ||..:|        |....||....:|..:...::..::.|.|.|       |    ||||..|.
Mouse    75 REEGQRRTPQGIGLLAKTPLSRPVKRNNAKYRRIQTLIYDALERPRGWALLYH----ALVFLIVL 135

  Fly   192 G-FFIAVSVMANVVETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAA---- 251
            | ..:||.......|||             .|:    ....|:|..:.||.||:.||::||
Mouse   136 GCLILAVLTTFKEYETV-------------SGD----WLLLLETFAIFIFGAEFALRIWAAGCCC 183

  Fly   252 -----PDRCKFVRSVMSIIDV---VAIMPYYIGLGITDNDDVSGAFVTLRVFRVFRIFKFSRHSQ 308
                 ..|.||.|..:.::|:   :|.:| .:.:| ...:.::.:..:||..::.|:.:..|...
Mouse   184 RYKGWRGRLKFARKPLCMLDIFVLIASVP-VVAVG-NQGNVLATSLRSLRFLQILRMLRMDRRGG 246

  Fly   309 GLRILGYTLKSCASEL------GFLVFSLAMAIIIFATVMFYAEKNVNGTN---------FTSIP 358
            ..::||..:.:.:.||      |||      .:|:.:.:::..||:|...:         |.:..
Mouse   247 TWKLLGSAICAHSKELITAWYIGFL------TLILSSFLVYLVEKDVPEMDAQGEEMKEEFETYA 305

  Fly   359 AAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFS---RIYHQNQRAD 420
            .|.|:.::|:.|:||||..|:|..|:::....||.||...|||..::.|..:   :..|:.:..:
Mouse   306 DALWWGLITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHFE 370

  Fly   421 KRK 423
            ||:
Mouse   371 KRR 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	1/1 (100%)
		Ion_trans	188..415	CDD:395416	61/257 (24%)
		DUF3399	445..540	CDD:403174
Kcnq3	NP_690887.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		Ion_trans	140..364	CDD:278921	59/248 (24%)
		Ion_trans_2	270..354	CDD:285168	25/89 (28%)
		Selectivity filter. /evidence=ECO:0000250	317..322		3/4 (75%)
		Mediates interaction with calmodulin. /evidence=ECO:0000250\|UniProtKB:O43525	357..538		3/17 (18%)
		KCNQ_channel	453..657	CDD:281513
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..603
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	723..742
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..873
		KCNQC3-Ank-G_bd	781..867	CDD:288784
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810