DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and kcng2

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	XP_017950308.2	Gene:	kcng2 / 100497537	XenbaseID:	XB-GENE-954003	Length:	489	Species:	Xenopus tropicalis

Alignment Length:	427	Identity:	145/427 - (33%)
Similarity:	227/427 - (53%)	Gaps:	42/427 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 DRRKTDD--EKLLINVSGRRFETWRNTLEKYPDTLLG-----SNEREFF-----YDEDCKEYFFD 86
            :|.:.:|  ..::|||.|.::.....|||..|.|.||     :|..|..     ||.:|.|:|||
Frog    52 NRGQLEDRTRHVIINVGGIKYRIPWTTLENCPLTRLGKLKTCNNYDEIMDVCDDYDINCNEFFFD 116

  Fly    87 RDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDD 151
            |:|..||.|:.:...|||...:..|..|:.|||.::||..:.:..||....:.::.|.||..|.:
Frog   117 RNPCAFRTIMTFLAAGKLRILREMCALSFQEELIYWGIEEEQLEWCCLRKLQQKEEELAEAKMYE 181

  Fly   152 KLS----ENGDQNLQQLTNMRQKMWR---AFENPHTSTSALVFYYVTGFFIAVSVMANVVETVPC 209
            ..|    ||....||....:.|.|..   ..||||:.....:|..::..|:|::.::..:.|:|.
Frog   182 GESGISNENSQSALQDSGRLAQCMKHLRDMVENPHSGIPGKIFACLSVSFVAITAVSLCISTMPD 246

  Fly   210 GHRPGRAGTLPCGER-YKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIMPY 273
            .......|  .|.:: |.|  |.|:|.||..|:.|::||...|..:|.|:|:.:::||::||:||
Frog   247 FRDEEDRG--ECSQKCYDI--FVLETVCVAWFSLEFVLRFIQAESKCVFLRTPLNMIDIMAILPY 307

  Fly   274 YIGL----------GITDNDDVSGAFVTLRVFRVFRI---FKFSRHSQGLRILGYTLKSCASELG 325
            ||.|          |...|:.:....:.|||.|..||   .:.:|||.||:.||.|::.|..|.|
Frog   308 YITLIVDALSGGKTGGAGNNYLEKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTVRRCTREFG 372

  Fly   326 FLVFSLAMAIIIFATVMFYAEKNVNG-TNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGV 389
            .|:..|.:|:.:|:.:::.||..:.. ..|||||.::|:.:::|||:|||||||.:|.|::|...
Frog   373 LLLLFLCVAMALFSPLVYLAENELGAKQEFTSIPGSYWWAVISMTTVGYGDMVPRSIPGQVVALS 437

  Fly   390 CSLSGVLVIALPVPVIVSNFSRIY----HQNQRADKR 422
            ..|||:|::|.||..|...|||.|    .|.|||.::
Frog   438 SILSGILLMAFPVTSIFHTFSRSYTELKEQQQRASRQ 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	39/121 (32%)
		Ion_trans	188..415	CDD:395416	86/245 (35%)
		DUF3399	445..540	CDD:403174
kcng2	XP_017950308.2	BTB_POZ_KCNG1_2	58..171	CDD:349728	38/112 (34%)
kcng2	XP_017950308.2	Ion_trans	222..465	CDD:395416	87/246 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000