DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and kcns3

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	XP_031758930.1	Gene:	kcns3 / 100497261	XenbaseID:	XB-GENE-952059	Length:	490	Species:	Xenopus tropicalis

Alignment Length:	421	Identity:	149/421 - (35%)
Similarity:	237/421 - (56%)	Gaps:	43/421 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RRKTDDEKLLINVSGRRFETWRNTLEKYPDTLLGS-----NEREFF-----YDEDCKEYFFDRDP 89
            |.|.::|.:.:||.|.:....:.||.::|.|.||.     :|....     |:...|||:|||:|
Frog     9 RTKNEEELVKLNVGGFKQSVDQKTLLRFPHTRLGKLLNCRSEEAILELCDDYNVADKEYYFDRNP 73

  Fly    90 DIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDKL- 153
            .:||:|||:|.|||||..:..|:.|:.:|:.::||....|..||...|:::|...||:..|.|.
Frog    74 SLFRYILNFYYTGKLHVMEELCVFSFSQEIEYWGINELFIDSCCSNKYQEKKEIIAEKDWDQKSD 138

  Fly   154 -----SENGDQ-----------NLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMAN 202
                 |.:.||           :..:..::|:|:|...|||..|.||.:|...:...:..|::|.
Frog   139 IISLGSSSSDQSSVFERELEMFDTLKFGDIRRKIWIRLENPAYSLSAKLFAIASLSVVLTSIVAM 203

  Fly   203 VVETVPCGHRPGRAGTLPCGER--YKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSII 265
            .:.::|      ....|...:|  ...|...::..|::.||:|.::||..||.:.||.::.|:||
Frog   204 CIHSMP------EFKKLDANDRELEDPVLAVVEIVCIIWFTSELVIRLIVAPSQKKFWKNPMNII 262

  Fly   266 DVVAIMPYYIGLGITDNDDVS------GAFV-TLRVFRVFRIFKFSRHSQGLRILGYTLKSCASE 323
            |.|:|:|:|..|.:..||:.:      |..| .||:.|:|||.|.:|||.|||.||.|||....|
Frog   263 DFVSIIPFYATLVVDVNDEENEGIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLKHSYHE 327

  Fly   324 LGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGG 388
            :|.|:..||:.|.||:.:::|.||:.:.:...|||..:|:..::|||:||||..|.|:.||:||.
Frog   328 VGLLLLFLAVGISIFSVLVYYVEKDEDQSGLHSIPMCWWWATISMTTVGYGDTHPVTLFGKLVGT 392

  Fly   389 VCSLSGVLVIALPVPVIVSNFSRIYHQNQRA 419
            ||.:.|:||:|||:.:|.:.||: |:|.|:|
Frog   393 VCIICGILVVALPITIIFNKFSK-YYQKQKA 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	42/118 (36%)
		Ion_trans	188..415	CDD:395416	87/235 (37%)
		DUF3399	445..540	CDD:403174
kcns3	XP_031758930.1	BTB_POZ_KCNS3	15..122	CDD:349735	38/106 (36%)
kcns3	XP_031758930.1	Ion_trans	185..421	CDD:395416	90/242 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910