DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and kcng4

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	XP_002934997.1	Gene:	kcng4 / 100497160	XenbaseID:	XB-GENE-985941	Length:	506	Species:	Xenopus tropicalis

Alignment Length:	428	Identity:	135/428 - (31%)
Similarity:	226/428 - (52%)	Gaps:	37/428 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 KLLINVSGRRFETWRNTLEKYPDTLLG-----SNEREFF-----YDEDCKEYFFDRDPDIFRHIL 96
            :::|||.|.::....:||:::|.|.||     |:..|..     :|||..|:||||:|..|..|:
Frog    61 EIIINVGGIKYLMPWSTLDEFPMTRLGKLRFCSSYEEIIQICDDFDEDTNEFFFDRNPCAFSMIV 125

  Fly    97 NYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDKLSENGD--- 158
            ::...|||...:..|..|:.:||.::||....:..||......:..|.||...:::...|.:
Frog   126 SFLAAGKLRLLREMCALSFQDELTYWGIEESKLERCCLRKLFQKLEELAEIRKEEEAQRNRETIC 190

  Fly   159 --QNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVPCGHRPGRAGTLPC 221
              ::..::.:...|:....|||.:.....||..::..|:|.:.:...|.|:|........|  .|
Frog   191 VLEDNTKVGHCMGKLRDMVENPQSGIPGKVFACLSIIFVATTAINLCVSTMPDLRAEEDRG--EC 253

  Fly   222 GER-YKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIMPYYIGLGITDNDDV 285
            .:. |.|  |.::|.||..|:.|:.||...|..:|:|.:..::||||:||:|||:.|.:.|....
Frog   254 SQMCYNI--FIIETICVAWFSLEFFLRFIQAKSKCQFFKGPLNIIDVLAILPYYVSLIVEDEQKT 316

  Fly   286 -----SGAFV--------TLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAIII 337
                 |.:::        .||..|:..:.:.:|||.||:.||.|::.|..|.|.|:..|.:|:.:
Frog   317 VDKPSSNSYLEKIGLVLRVLRALRILYVMRLARHSLGLQTLGLTVRRCTREFGLLLLFLCVAVTL 381

  Fly   338 FATVMFYAEKNVNG-TNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALP 401
            ||.::..||..:.. ..|||:||::|:.|::|||:|||||||.:|.|::|.....|||:|::|.|
Frog   382 FAPLVHLAENEMGRCQEFTSVPASYWWAIISMTTVGYGDMVPRSIPGQVVALSSILSGILIMAFP 446

  Fly   402 VPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKAS 439
            ...|...|||.|.:.:|..:|   .::||.|::.|..|
Frog   447 ATSIFHTFSRCYSELKREQER---LQSRLMRLKDANQS 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	34/111 (31%)
		Ion_trans	188..415	CDD:395416	84/241 (35%)
		DUF3399	445..540	CDD:403174
kcng4	XP_002934997.1	BTB_POZ_KCNG4	59..170	CDD:349730	34/108 (31%)
kcng4	XP_002934997.1	Ion_trans	219..462	CDD:366146	86/246 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000