DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and kcnc4

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	XP_002933043.1	Gene:	kcnc4 / 100492941	XenbaseID:	XB-GENE-6032635	Length:	598	Species:	Xenopus tropicalis

Alignment Length:	526	Identity:	177/526 - (33%)
Similarity:	279/526 - (53%)	Gaps:	94/526 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PP----MPKDRRKTDDE-KLLINVSGRRFETWRNTLEKYPDTLL--------GSNEREFFYDEDC 80
            ||    :.::..|.:|. |:.|||.|.|.||:::||...|.|.|        .||...   |...
Frog    19 PPSKTCLKEEMAKGEDSGKITINVGGTRHETYKSTLRTLPGTRLAWLADPDTASNSES---DSQR 80

  Fly    81 KEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRD-RKREN 144
            .|:||||.|.||.::||||||||||.|...|...::|||||:||....:..||:..||. |..|.
Frog    81 TEFFFDRHPGIFSYVLNYYRTGKLHCPADICGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEE 145

  Fly   145 AERLMDDKLSENGDQN----------LQQLTN--------MRQKMWRAFENPHTSTSALVFYYVT 191
            |..:.::...|:|::.          :::.|:        .:.|||..||:|::|.:|.|..:|:
Frog   146 ALDIFENVEPEDGEEENKGSSPELLCIEERTDRSRGCWKVWQPKMWALFEDPYSSRAARVVAFVS 210

  Fly   192 GFFIAVSVMA-------------NVVETVPCGHRP-----GRAGTLPCGERYKIVFFCLDTACVM 238
            .|||.:|:..             ||.|||..|:..     ....|.|       :...::..||.
Frog   211 LFFILMSITTFCLETHESFIVDRNVTETVTIGNMTEILVVREVETEP-------ILTYIEGVCVF 268

  Fly   239 IFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIMPYYIGLGITDND-----DVSGAFVTLRVFRVF 298
            .||.|:|:|:...||:..||:::::|||.|||:|:|:.:|::...     ||.|....:|..|:.
Frog   269 WFTLEFLVRIICCPDKVFFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRIL 333

  Fly   299 RIFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATVMFYAEK---------NVNGTNF 354
            ||||.:||..|||:||:||::..:|...|:..||:.::||||:::|||:         ..|.|:|
Frog   334 RIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGANPTDPSGSNHTHF 398

  Fly   355 TSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYH---QN 416
            .:||..||:.:|||||||||||.|:|.:|.:||.:|:|:|||.||:||||||:||...|.   ..
Frog   399 KNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAK 463

  Fly   417 QRADKRKAQRKARLARI-------------RIAKASS----GAAFVSKKKAAEARWAAQESGIEL 464
            |:..|:|.:...:.:::             |.:..|.    .|..:::||.::::.....:.:..
Frog   464 QKLPKKKKKHVPKTSQMDSQTTLKSEDNSHRNSTQSDTCPLAAEELTEKKRSDSKQNGDANAVMS 528

  Fly   465 DDNYRD 470
            |:::.|
Frog   529 DEDHED 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	52/128 (41%)
		Ion_trans	188..415	CDD:395416	101/261 (39%)
		DUF3399	445..540	CDD:403174	4/26 (15%)
kcnc4	XP_002933043.1	Potassium_chann	1..29	CDD:314363	2/9 (22%)
		BTB_POZ	34..150	CDD:365784	51/118 (43%)
		Ion_trans	203..461	CDD:366146	103/264 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910