DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and kcnd1

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	XP_031747765.1	Gene:	kcnd1 / 100488387	XenbaseID:	XB-GENE-6047565	Length:	631	Species:	Xenopus tropicalis

Alignment Length:	533	Identity:	358/533 - (67%)
Similarity:	429/533 - (80%)	Gaps:	9/533 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASVAAWLPFARAAAIGWVPIATHPLPPPPMPKDRRKTDDEKLLINVSGRRFETWRNTLEKYPDTL 66
            |.||.|||||||||:||:|:|..|:|.|  |.|:|...||.|::|||||:|:||:|||::|||||
Frog     3 AGVATWLPFARAAAVGWLPLAKRPMPKP--PSDKRMKSDEILVVNVSGRKFQTWKNTLDRYPDTL 65

  Fly    67 LGSNEREFFYDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGD 131
            |||.|::||:::|.:||||||||::||||||:|||||||||:|||:.::||||:|:||:|::|||
Frog    66 LGSTEKDFFFNQDTQEYFFDRDPEMFRHILNFYRTGKLHYPRHECIQAFDEELSFYGIIPEIIGD 130

  Fly   132 CCYEDYRDRKRENAERLMDDKLSEN-GDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFI 195
            ||.|:|||||:||.|||.:|..:|. ||..|...:..||::|||||||||||.||||||||||||
Frog   131 CCLEEYRDRKKENLERLAEDTEAETAGDTPLPPDSTFRQRLWRAFENPHTSTMALVFYYVTGFFI 195

  Fly   196 AVSVMANVVETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRS 260
            ||||:|||||||||....||...|||||:|.:.|.|:|||||:|||.|||:||||||.||||:||
Frog   196 AVSVIANVVETVPCRPPAGRLKELPCGEKYNLAFVCMDTACVLIFTFEYLMRLFAAPSRCKFMRS 260

  Fly   261 VMSIIDVVAIMPYYIGLGITDNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELG 325
            ||||||||||||:||||.:.:|::|||||||||||||||||||||||||||||||||||||||||
Frog   261 VMSIIDVVAIMPFYIGLVMPENENVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELG 325

  Fly   326 FLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVC 390
            ||:|||.|||||||||||||||..:.|.|||||||||||||||||||||||||:||||||.|.:|
Frog   326 FLLFSLTMAIIIFATVMFYAEKGTSKTKFTSIPAAFWYTIVTMTTLGYGDMVPDTIAGKIFGSIC 390

  Fly   391 SLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSGAAFVSKKKAAEARW 455
            ||||||||||||||||||||||||||||||||:||:|.||||||:||:::..||:..|::.....
Frog   391 SLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQKIRLARIRLAKSNTTGAFLRYKESGGLEE 455

  Fly   456 AAQESGIELDDNYRDEDIFELQHHHLLRCLEKTTDREFVELEIPFNGQPKRPGSPSPMASPAHST 520
            ..:...:.:    ::...|||||||||.||||||..||.:...  ..:.....|.....|.:.|.
Frog   456 GTESHALCV----KNRSAFELQHHHLLHCLEKTTCHEFTDQHT--YSEALMTESIGYRTSRSTSV 514

  Fly   521 NSAAGLLQSCCGR 533
            :|..|...|||.|
Frog   515 SSQQGFGTSCCPR 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	90/137 (66%)
		Ion_trans	188..415	CDD:395416	189/226 (84%)
		DUF3399	445..540	CDD:403174	27/89 (30%)
kcnd1	XP_031747765.1	BTB_POZ_KCND1	6..143	CDD:349724	91/138 (66%)
		Ion_trans	184..415	CDD:395416	193/230 (84%)
		DUF3399	445..542	CDD:403174	27/89 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	398	1.000	Domainoid score	I741
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	747	1.000	Inparanoid score	I577
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221939at33208
OrthoFinder	1	1.000	-	-		FOG0001867
OrthoInspector	1	1.000	-	-		otm48640
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060