DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shal and kcnv1

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	XP_002939028.1	Gene:	kcnv1 / 100487006	XenbaseID:	XB-GENE-956997	Length:	503	Species:	Xenopus tropicalis

Alignment Length:	487	Identity:	157/487 - (32%)
Similarity:	245/487 - (50%)	Gaps:	71/487 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PMPKDRRKTDDEKLLINVSGRRFETWRNTLEKYPDTLLG----SNEREFFYDEDC-------KEY 83
            |.|||.       |.|||.|.||......|..:|:|.||    |..:|.:  |.|       .||
Frog    55 PAPKDH-------LTINVGGSRFILSHKVLSNHPETRLGRLVSSGGQEVY--ELCDDANLMDNEY 110

  Fly    84 FFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRK--RENAE 146
            ||||...:|::|:|:|:||.||..:..|..|:.:|:.::||....|..||.|.|..:|  .|:.:
Frog   111 FFDRSSQMFKYIMNFYKTGHLHVMEELCAVSFLQEIQYWGIDELNIDLCCRERYYRKKLMSESLD 175

  Fly   147 RLMDDKLSENGDQNLQQLT--NMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVPC 209
            ...|::..|..:::...:.  :.||.:|...|.|.:|.:|..|..::..||.:|: ||:|
Frog   176 IKKDEEEIEAEEEDFSGVVFEHFRQTLWDILEKPGSSVAAKTFGTLSMTFIVISI-ANMV----- 234

  Fly   210 GHRPGRAGTLPCGERYKI---VFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIM 271
                     |...|...|   :...|:..|:..||.|..||......:|:|:|||::|||:|||:
Frog   235 ---------LISSEMNSIDPPLLNALEYICITWFTLELALRFLCVKHKCRFLRSVVNIIDIVAIL 290

  Fly   272 PYYIGLGI-------TDNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLVF 329
            |:||.|.:       |:.::|.....:||:.|..|:.|..|||.||:.||.|:..|..|:|.|:.
Frog   291 PFYITLIVENLYGESTELENVGRIVQSLRLLRSLRMLKLGRHSTGLKSLGMTIAQCYEEVGLLLL 355

  Fly   330 SLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSG 394
            .|::.|.||:.:.:..|.|:..|.|||:|.|:|:...:|||:||||:.|:|..||||..:|.|||
Frog   356 FLSVGISIFSALEYAVEHNIPDTTFTSVPNAWWWATTSMTTVGYGDIRPDTTFGKIVAFLCILSG 420

  Fly   395 VLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSGAAFVSKKKAAEARWAAQE 459
            :||:|||:.:|...|:..|...:..:....||:|                  .||..:...|..:
Frog   421 ILVLALPIAIINDRFAACYFTLKIKEAALRQREA------------------LKKLMKNISAESD 467

  Fly   460 SGIELDDNYRDEDIFELQHHHLLRCLEKTTDR 491
            :.:.|.|.|. :.:.|:..   |:..|:.:.|
Frog   468 TNVNLRDIYA-KSVMEMLR---LKSRERASTR 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	45/126 (36%)
		Ion_trans	188..415	CDD:395416	88/236 (37%)
		DUF3399	445..540	CDD:403174	10/47 (21%)
kcnv1	XP_002939028.1	BTB_POZ_KCNV1	61..169	CDD:349731	40/109 (37%)
kcnv1	XP_002939028.1	Ion_trans	215..439	CDD:366146	89/238 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000