DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and kcnf1b

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	XP_005157014.1	Gene:	kcnf1b / 100334378	ZFINID:	ZDB-GENE-090312-39	Length:	484	Species:	Danio rerio

Alignment Length:	465	Identity:	143/465 - (30%)
Similarity:	241/465 - (51%)	Gaps:	57/465 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 MPKDR-------RKTDDEKLLINVSGRRFETWRNTLEKYPDT----LLGSNEREF--------FY 76
            :|:.|       ..:|::::.:|:.|.|.....:.|.:|||:    |:....|.|        .|
Zfish     4 LPRTRFAHCNSSSSSDEKEIAVNIGGVRLVLCGDILNRYPDSRLAELVNCPTRSFDVISSLCDDY 68

  Fly    77 DEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRK 141
            |...:|::||||||.|:.|:..|..|::|..:..|...:.:|:.|:.|....:.:||..:..:::
Zfish    69 DPGKREFYFDRDPDSFKCIVEVYYFGEVHMKRGICPICFIKEMEFWKIDLSYLDECCKSNLTEKE 133

  Fly   142 RENAE-----RLMDDKLSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMA 201
            .|.||     :|:.|.|  ..|..:.:....::.:|:..|.|.:|..|.|...|:..||.:|
Zfish   134 EELAEIADKVKLILDDL--ECDPAVSRTERWQKFVWKLMEKPESSLPARVIAVVSFLFILIS--- 193

  Fly   202 NVVETVPCGHRPGRAGTLPC-------GERYKIVFF-CLDTACVMIFTAEYLLRLFAAPDRCKFV 258
               ..|.|      .||||.       |.|.:.... .::|||:..||.||:|||.::|::.:|.
Zfish   194 ---SVVMC------LGTLPDLQVEDSEGNRVEHPSLDAIETACIGWFTVEYVLRLASSPNKLRFA 249

  Fly   259 RSVMSIIDVVAIMPYYI-------GLGITDNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYT 316
            .|.|::||.:|::|:|:       |..:.:..:|..|...||:.|:.||||.:|||.||:.|.|.
Zfish   250 LSFMNMIDFLAVLPFYVVLVLTCLGTAMMELVNVQQAVQALRIMRIARIFKLARHSSGLQTLTYA 314

  Fly   317 LKSCASELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETI 381
            ||....|||.|:..:.:.|.:|:.:.:..|::...|.|.|||.:||:.|:||||:||||:.|:|.
Zfish   315 LKRSFKELGLLLMYMGVGIFVFSALGYTMEQSHPETLFRSIPQSFWWAIITMTTVGYGDIYPKTT 379

  Fly   382 AGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSGAAFVS 446
            .|:....:..|.||:.||||:..|::||. ||:..|:..:..|:.:..|..:|..:.:..:|  |
Zfish   380 LGRCNAAISFLCGVIAIALPIHPIINNFV-IYYNKQKVLETAAKHELELMELRALELTVRSA--S 441

  Fly   447 KKKAAEAR-W 455
            ::..|..| |
Zfish   442 RRSDAPGRAW 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	33/131 (25%)
		Ion_trans	188..415	CDD:395416	88/241 (37%)
		DUF3399	445..540	CDD:403174	4/12 (33%)
kcnf1b	XP_005157014.1	BTB	23..129	CDD:197585	30/105 (29%)
		BTB	23..124	CDD:295341	28/100 (28%)
		Ion_trans	220..415	CDD:278921	76/195 (39%)
		Ion_trans_2	331..398	CDD:285168	26/66 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910